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Merck
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重要文件

M5449

Sigma-Aldrich

MKT-077

≥98% (HPLC), powder

同義詞:

1-乙基-2- [[3-乙基-5-(3-甲基-2 (3H)-苯并噻唑亚甲基)-4-氧代-2-噻唑亚基] 甲基]-氯化吡啶, FJ-776

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About This Item

線性公式:
C21H22N3OS2Cl
CAS號碼:
分子量::
432.00
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

orange to red

溶解度

H2O: 10 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CN(C1=C(S/2)C=CC=C1)C2=C3C(N(CC)/C(S\3)=C/C4=[N+](CC)C=CC=C4)=O.[Cl-]

InChI

1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21;/h6-14H,4-5H2,1-3H3;1H/q+1;/p-1/b21-19+;

InChI 密鑰

VSKYOTRJSLYFHX-UXJRWBAGSA-M

生化/生理作用

MKT-077 是线粒体 hsp70 家族成员致死蛋白 (mot-2) n 的抑制剂
MKT-077 是线粒体 hsp70 家族成员致死蛋白 (mot-2) n 的抑制剂;它导致癌细胞选择性死亡。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Rachel A Rigg et al.
American journal of physiology. Cell physiology, 310(7), C568-C575 (2016-01-15)
Molecular chaperones that support protein quality control, including heat shock protein 70 (Hsp70), participate in diverse aspects of cellular and physiological function. Recent studies have reported roles for specific chaperone activities in blood platelets in maintaining hemostasis; however, the functions
Sujit Pujhari et al.
Emerging microbes & infections, 8(1), 8-16 (2019-03-15)
Zika virus (ZIKV) is a historically neglected mosquito-borne flavivirus that has caused recent epidemics in the western hemisphere. ZIKV has been associated with severe symptoms including infant microcephaly and Guillain-Barré syndrome, stimulating interest in understanding factors governing ZIKV infection. Heat
Sunil Joseph et al.
Biology open, 6(4), 481-488 (2017-03-16)
Earlier studies suggested that
Ahmed Edan Dhamad et al.
American journal of physiology. Cell physiology, 318(2), C289-C303 (2019-12-05)
Glucose-regulated protein 75 (GRP75) was first characterized in mammals as a heat shock protein-70 (HSP70) family stress chaperone based on its sequence homology. Extensive studies in mammals showed that GRP75 is induced by various stressors such as glucose deprivation, oxidative
Tuoen Liu et al.
PloS one, 12(2), e0170470-e0170470 (2017-02-09)
Myelodysplastic syndromes (MDS) are the most common adult myeloid blood cancers in the US. Patients have increased apoptosis in their bone marrow cells leading to low peripheral blood counts. The full complement of gene mutations that contribute to increased apoptosis

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