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About This Item
經驗公式（希爾表示法）:
C25H23Cl2N7O4
CAS號碼:
分子量：:
556.40
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to light brown
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
Nc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc5ccc(Cl)c(Cl)c5)nc12
InChI
1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
InChI 密鑰
ZXGGCBQORXDVTE-UMCMBGNQSA-N
應用
VER-155008 可用作热休克蛋白 70（HSP70）的抑制剂：
- 研究其对人胚胎肾 293（HEK293T）细胞的作用
- 研究其对 Vero E6 细胞中病毒 mRNA 合成及蛋白表达的影响
- 研究其对大鼠癫痫发作的衰减作用
生化／生理作用
VER-155002是HSP70的小分子、ATP衍生物抑制剂（IC50 = 500 nM）。该化合物能够抑制多种结肠癌和乳腺癌细胞系的增殖，诱导BT474细胞的半胱天冬酶依赖性细胞凋亡，并下调HCT116细胞的Her2和Raf-1表达。
VER-155002是一种Hsp70抑制剂。
VER‐155008 可积极促进记忆恢复和轴突再生。此外，它还参与抑制非小细胞肺癌（NSCLC）的细胞周期进程和增殖。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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