373260

Heat Shock Protein Inhibitor I

Heat Shock Protein Inhibitor I, CAS 218924-25-5 blocks the induction of HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.

• 同義詞: Heat Shock Protein Inhibitor I, KNK437, N-Formyl-3,4-methylenedioxy-benzylidine-γ-butyrolactam, Hsp70 Induction Inhibitor I
• 經驗公式（希爾表示法）: C₁₃H₁₁NO₄
• CAS號碼: 218924-25-5
• 分子量：: 245.23
• MDL號碼: MFCD24369049
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white to light yellow
• 溶解度: DMSO: 3 mg/mL; olive oil: soluble
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N1(CCC(=Cc2cc3c(cc2)OCO3)C1=O)C=O
• InChI 密鑰: LZGGUFLRKIMBDQ-UHFFFAOYSA-N

描述

一般說明

A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner. Does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600); and unlike Quercetin, it does not have an affect on the activities of PKA, PKC, or PTK.

A benzylidine lactam compound that inhibits the induction of heat shock proteins, including HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner, but does not affect the thermosensitivity of nontolerant cells. Reported to be less toxic and more effective than Quercetin (Cat. No. 551600), and, unlike quercetin, it does not affect the activities of PKA, PKC, and PTK.

生化／生理作用

Cell permeable: no

Primary Target
Hsp70

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 weeks at -20°C.

其他說明

Koishi, M., et al. 2001. Clin. Cancer Res.7, 215.
Yokota, S., et al. 2000. Cancer Res.60, 2942.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable