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About This Item
經驗公式（希爾表示法）:
C8H7NO2S
CAS號碼:
分子量：:
181.21
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥97% (HPLC)
形狀
solid
儲存條件
desiccated
溶解度
DMSO: soluble >10 mg/mL, clear
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
NS(=O)(=O)C#Cc1ccccc1
InChI
1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChI 密鑰
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
應用
菲丝菌素-μ 已用于:
- 处理小胶质细胞系以分析其对M1样和M2样表型的神经保护作用
- 作为热休克蛋白（HSP）-70抑制剂用于处理转染的Marc-145细胞
- 抑制热休克相关蛋白70（heat shock cognate，Hsc70）以阐明小鼠胚胎干细胞的热休克伴侣蛋白
生化／生理作用
Pifithrin- μ是p53结合和抗凋亡的抑制剂，其可直接抑制p53与线粒体以及Bcl-xL和Bcl-2蛋白的结合。PFT μ可从致死γ -辐射诱导的细胞死亡中解救细胞。由于pifithrin- μ仅关闭p53-线粒体途径而不影响p53的转录功能，所以它比pifithrin-α 具有更优的性能。
在缺氧缺血（HI）诱发的新生儿脑病的临床前模型中，菲丝菌素μ（PFT-μ）具有防止细胞死亡的神经保护能力。它通过抑制分子伴侣热休克蛋白（HSP）-70与其底物的相互作用来抑制核因子ΙB（NF-ΙB）通路。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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