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Merck

860584P

Avanti

16:0 SM (d18:1/16:0)

Avanti Research - A Croda Brand, powder

别名:

N-棕榈酰-D-赤-鞘氨醇磷酸胆碱

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About This Item

经验公式(希尔记法):
C39H79N2O6P
CAS号:
分子量:
703.03
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

>99% (TOF, LC/MS)

形狀

powder

包裝

pkg of 1 × 10 mg (860584P-10mg)
pkg of 1 × 25 mg (860584P-25mg)
pkg of 1 × 5 mg (860584P-5mg)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C39H79N2O6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-38(42)37(36-47-48(44,45)46-35-34-41(3,4)5)40-39(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h30,32,37-38,42H,6-29,31,33-36H2,1-5H3,(H-,40,43,44,45)/b32-30+/t37-,38+/m0/s1

InChI 密鑰

RWKUXQNLWDTSLO-GWQJGLRPSA-N

應用

N-棕榈酰-D-赤型-鞘氨醇磷酰胆碱(16:0 SM(d18:1/16:0))可作为标准品,定量鞘脂代谢物。 也可以通过电喷雾电离串联质谱(ESI-MS / MS),对绿色荧光蛋白(GFP)和脂肪酸转运蛋白4(FATP4)细胞中的脂质进行定量。还可用于测定脂质体中OstreolysinA(OlyA)的结合情况,确定磷脂酰胆碱(PCs)对鞘磷脂(SM)/胆固醇相互作用的影响。

包裝

5 mL棕色玻璃螺旋盖样品瓶(860584P-10mg)
5 mL棕色玻璃螺旋盖样品瓶(860584P-25mg)
5 mL棕色玻璃螺旋盖样品瓶(860584P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Elisabeth Corcelle-Termeau et al.
Autophagy, 12(5), 833-849 (2016-04-14)
Sphingomyelin is an essential cellular lipid that traffics between plasma membrane and intracellular organelles until directed to lysosomes for SMPD1 (sphingomyelin phosphodiesterase 1)-mediated degradation. Inactivating mutations in the SMPD1 gene result in Niemann-Pick diseases type A and B characterized by
Elisabetta Albi et al.
International journal of molecular sciences, 15(7), 11555-11565 (2014-07-01)
Proliferating thyroid cells are more sensitive to UV-C radiations than quiescent cells. The effect is mediated by nuclear phosphatidylcholine and sphingomyelin metabolism. It was demonstrated that proton beams arrest cell growth and stimulate apoptosis but until now there have been
Ebru Afşar et al.
Redox biology, 30, 101430-101430 (2020-01-25)
We aimed to determine sphingolipid levels and examine apoptotic pathways in human retinal pigment epithelial cells (ARPE-19) undergoing endoplasmic reticulum (ER) stress. Cells were treated with tunicamycin (TM) to induce ER stress and tauroursodeoxycholic acid (TUDCA), an ER stress inhibitor
Jung Yong Eum et al.
Journal of chromatography. A, 460849-460849 (2020-01-14)
Aging refers to the intracellular accumulation of reactive oxygen species that damages proteins, DNA, and lipids. As alterations in lipid metabolism may trigger metabolic disorders and the onset of metabolic diseases, changes in lipid profiles can be closely related to
Delphine Milhas et al.
FEBS letters, 584(9), 1887-1894 (2009-10-28)
The plasma membrane (PM) is a major resource for production of bioactive lipids and contains a large proportion of the cellular sphingomyelin (SM) content. Consequently, the regulation of SM levels at the PM by enzymes such as sphingomyelinase (SMase) and

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