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Merck

850457P

Avanti

16:0-18:1 PC

Avanti Polar Lipids

别名:

1-棕榈酰基-2-(9Z-油酰)-sn-甘油-3-磷酰胆碱;POPC;PC(16:0/18:1(9Z))

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About This Item

经验公式(希尔记法):
C42H82NO8P
CAS号:
分子量:
760.08
分類程式碼代碼:
51191904
NACRES:
NA.25

描述

1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 g (850457P-1g)
pkg of 2 × 100 mg (850457P-200mg)
pkg of 5 × 100 mg (850457P-500mg)
pkg of 1 × 25 mg (850457P-25mg)

製造商/商標名

Avanti Polar Lipids

脂質類型

phospholipids
cardiolipins

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O

InChI

1S/C42H82NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h20-21,40H,6-19,22-39H2,1-5H3/b21-20-/t40-/m1/s1

InChI 密鑰

WTJKGGKOPKCXLL-VYOBOKEXSA-N

一般說明

POPC通常被作为一种模型脂质,用于生物物理实验。脂肪酸组分,即sn-1位的饱和链和sn-2位的不饱和链,可模拟哺乳动物的磷脂组分。由于Egg PC的主要成分是1-棕榈酰-2-油酰PC,因此,POPC是EPC的优良合成替代品。

應用

16:0-18:1 PC用于制备脂质体,包裹胞壁酰三肽。也用于制备膜支架蛋白1纳米光盘。16:0-18:1 PC可用于合成盘状重构的高密度脂蛋白。

生化/生理作用

1-棕榈酰-2-油酰-甘油-3-磷酸胆碱(POPC)或16:0-18:1 PC作为肺表面活性剂发挥重要作用,降低表面张力。POPC模拟天然细胞膜,可用于不饱和脂质的氧化研究。它与臭氧相互作用,使油酰链C-C键氧化分解。

包裝

5 mL透明玻璃密封安瓿瓶(850457P-200mg)
5 mL透明玻璃密封安瓿瓶(850457P-25mg)
5 mL透明玻璃密封安瓿瓶(850457P-500mg)
60 mL琥珀色宽口螺帽玻璃瓶(850457P-1g)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

分析证书(COA)

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Modified apolipoprotein (apo) AI by artificial sweetener causes severe premature cellular senescence and atherosclerosis with impairment of functional and structural properties of apoA-I in lipid-free and lipid-bound state
Jang W, et al.
Molecules and Cells, 31(5), 461-470 (2011)
Oxidative degradation of the monolayer of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) in low-level ozone
Qiao L, et al.
The Journal of Physical Chemistry B, 119(44), 14188-14199 (2015)
Fluorophore Labeling, Nanodisc Reconstitution and Single-molecule Observation of a G Protein-coupled Receptor
Lamichhane R, et al.
Bio-protocol, 7(12) (2017)
Michael J Hallock et al.
Biochemistry, 57(50), 6897-6905 (2018-11-21)
The plasma membrane of the cell is a complex, tightly regulated, heterogeneous environment shaped by proteins, lipids, and small molecules. Ca2+ ions are important cellular messengers, spatially separated from anionic lipids. After cell injury, disease, or apoptotic events, anionic lipids
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ACS nano, 12(5), 4478-4485 (2018-04-17)
Giant unilamellar vesicles (GUVs) provide a direct connection between the nano- and the microregime. On the one hand, these vesicles represent biomimetic compartments with linear dimensions of many micrometers. On the other hand, the vesicle walls are provided by single

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