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Merck

860061P

Avanti

鸡蛋 SM

Avanti Research - A Croda Brand

别名:

16:0 SM;十六烷酰鞘磷脂; N-十六烷酰基-D-赤型鞘氨酰基磷酰胆碱; N-(十六烷酰基)-鞘氨醇-1-磷酸胆碱

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About This Item

分類程式碼代碼:
12352211
NACRES:
NA.25

描述

Sphingomyelin (Egg, Chicken)

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 g (860061P-1g)
pkg of 1 × 200 mg (860061P-200mg)
pkg of 1 × 25 mg (860061P-25mg)

製造商/商標名

Avanti Research - A Croda Brand

脂質類型

sphingolipids

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C39H79N2O6P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-38(42)37(36-47-48(44,45)46-35-34-41(3,4)5)40-39(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h30,32,37-38,42H,6-29,31,33-36H2,1-5H3,(H-,40,43,44,45)/b32-30+/t37-,38+/m0/s1

InChI 密鑰

RWKUXQNLWDTSLO-GWQJGLRPSA-N

一般說明

作为细胞膜的主要成分,鞘磷脂在神经细胞(髓鞘)膜和红细胞膜中的浓度特别高。以前认为,它是因鞘氨醇碱基的2-酰胺基、3-羟基和4,5-反式双键介导的分子间相互作用而具有与磷脂酰胆碱功能相似的纯结构作用。但是,现在人们认识到,鞘磷脂对胆固醇具有高亲和力,这两种脂质在液体无序相中紧密堆积成液体有序结构域,形成脂质筏。这些膜微结构域被认为是调节蛋白质定位和相互作用的信号转导平台。但是,鞘磷脂不仅是会影响信号传导的脂质筏成分,它还是神经酰胺和其他鞘脂代谢(包括鞘磷脂循环或鞘脂网络)产物的前体。
鞘磷脂和相关脂质

應用

蛋黄SM可用于制备鞘磷脂(SM)标准溶液。还可用于制备脂质体。

包裝

20 mL透明玻璃螺旋盖样品瓶(860061P-1g)
5 mL棕色玻璃螺旋盖样品瓶(860061P-200mg)
5 mL棕色玻璃螺旋盖样品瓶(860061P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids


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eLife, 8 (2019-10-29)
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016). But how is cholesterol, an abundant lipid, regulated tightly enough to control a signaling
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Langmuir : the ACS journal of surfaces and colloids, 34(1), 465-471 (2017-12-13)
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Biophysical journal, 115(8), 1498-1508 (2018-10-03)
Membrane viscosity and hydration levels characterize the biophysical properties of biological membranes and are reflected in the rate and extent of solvent relaxation, respectively, of environmentally sensitive fluorophores such as Laurdan. Here, we first developed a method for a time-resolved

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