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P3662

Sigma-Aldrich

Sodium pyruvate

Hybri-Max™, powder, suitable for hybridoma

Synonym(s):

α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt

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About This Item

Linear Formula:
CH3COCOONa
CAS Number:
113-24-6
Molecular Weight:
110.04
Beilstein/REAXYS Number:
3568341
EC Number:
204-024-4
MDL number:
MFCD00002586
UNSPSC Code:
12352205
PubChem Substance ID:
24898440
NACRES:
NA.75

biological source

synthetic (organic)

Quality Level

200

grade

Hybri-Max™

assay

≥99%

form

powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

mp

>300 °C (lit.)

solubility

H2O: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

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Application

Sodium pyruvate has been used as a component in maturation medium for oocyte evaluation.
Sodium pyruvate is used by cells as an easily accessible carbohydrate source. Additionally, it is involved with amino acid metabolism and initiates the Kreb′s cycle. The 100 mM solution should be diluted 1:100 for most cell culture applications.

Biochem/physiol Actions

Sodium pyruvate is known to be an effective therapeutic target for type II citrullinaemia which is characterized by hyperammonaemia. In vivo studies proves that sodium pyruvate has protective function against hemorrhagic shock by preventing lipid peroxidation, NAD+ reduction and cleavage of poly(ADP-ribose) polymerases. Sodium pyruvate is also known to possess anti-inflammatory action and might show improvement in chronic lung disorder.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1B

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Developmental competence and mRNA expression of preimplantation in vitro-produced embryos from prepubertal and postpubertal cattle and their relationship with apoptosis after intraovarian administration of IGF-1
Zaraza J, et al.
Theriogenology, 74(1), 75-89 (2010)
Characterisation of low, medium and high responders following FSH stimulation prior to ultrasound-guided transvaginal oocyte retrieval in cows
De RR, et al.
Animal Reproduction Science, 63(7), 1902-1913 (2005)
Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury
Fukushima M, et al.
Journal of Neurotrauma, 26(7), 1095-1110 (2009)
Ovum pick up and in vitro embryo production in cows superstimulated with an individually adapted superstimulation protocol
De R, et al.
Animal Reproduction Science, 86(1-2), 13-25 (2005)
Treatment of a citrin-deficient patient at the early stage of adult-onset type II citrullinaemia with arginine and sodium pyruvate
Mutoh K, et al.
Journal of inherited metabolic disease, 31(2), 343-347 (2008)
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