MilliporeSigma
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P4562

Sigma-Aldrich

Sodium pyruvate

powder, BioXtra, suitable for mouse embryo cell culture

Synonym(s):
α-Ketopropionic acid sodium salt, 2-Oxopropanoic acid sodium salt, Pyruvic acid sodium salt
Linear Formula:
CH3COCOONa
CAS Number:
Molecular Weight:
110.04
Beilstein:
3568341
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.75

product line

BioXtra

Quality Level

assay

≥99%

form

powder

technique(s)

cell culture | embryo: suitable

mp

>300 °C (lit.)

solubility

H2O: 100 mg/mL

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

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General description

Pyruvate, the end-product of the glycolysis pathway,[42] is the anion of pyruvic acid.

Application

Sodium pyruvate has been used:
  • as a supplement in Ca2+ + N-Tris(hydroxymethil)methyl-2-aminoethanesulfonic acid (TES)–NaCl medium for sperm incubation
[43]
  • as a supplement in TCM-199 hepes modification solution for cumulus-oocytes complexes (COC′s) culture
  • [67]
  • as a supplement in Dulbecco′s modified Eagle medium (DMEM) to culture mouse primary hepatocytes (MPHs) and also to intraperitoneally inject fasted mice for glucose production assessment
  • [48]

    Packaging

    5, 25, 100 g in poly bottle

    Biochem/physiol Actions

    Sodium pyruvate is mainly used as a constituent in culture broth and media. It exhibits anti-oxidation and anti-inflammatory properties. Hence sodium pyruvate is considered a possible therapy for allergic rhinitis.[50] Sodium pyruvate might also be a new approach treating lactic acidosis.[47]
    Sodium pyruvate is used by cells as an easily accessible carbohydrate source. Additionally, it is involved with amino acid metabolism and initiates the Kreb′s cycle. Sodium pyruvate attenuates oxidative stress in vitro. The 100 mM solution should be diluted at 1:100 for most cell culture applications. This product has been qualified for use in mouse embryo cultures.

    Pictograms

    Exclamation mark

    Signal Word

    Warning

    Hazard Statements

    Hazard Classifications

    Eye Irrit. 2 - Skin Sens. 1B

    Storage Class Code

    13 - Non Combustible Solids

    WGK

    WGK 1

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

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    Certificate of Origin

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