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L6026

Sigma-Aldrich

Sodium dodecyl sulfate

BioXtra, ≥99.0% (GC)

Synonym(s):

Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate

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About This Item

Linear Formula:
CH3(CH2)11OSO3Na
CAS Number:
Molecular Weight:
288.38
Beilstein/REAXYS Number:
3599286
EC Number:
MDL number:
UNSPSC Code:
12161900
eCl@ss:
39093306
PubChem Substance ID:
NACRES:
NA.21

biological source

synthetic (oragnic)

Quality Level

description

anionic

product line

BioXtra

assay

≥99.0% (GC)

form

powder

mol wt

micellar avg mol wt 18,000

aggregation number

62

impurities

Insoluble matter, passes filter test

loss

≤0.5% loss on drying, HV, 20-25 °C

CMC

7-10 mM (20-25°C)

mp

204-207 °C (lit.)

transition temp

cloud point >100 °C

solubility

H2O: 0.1 M, clear, colorless

density

0.496 g/cm3

anion traces

chloride (Cl-): ≤0.05%
phosphate (PO43-): ≤0.0001%

cation traces

Al: ≤0.0005%
Ba: ≤0.0005%
Bi: ≤0.0005%
Ca: ≤0.001%
Cd: ≤0.0005%
Co: ≤0.0005%
Cr: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.02%
Li: ≤0.0005%
Mg: ≤0.0005%
Mn: ≤0.0005%
Mo: ≤0.0005%
Ni: ≤0.0005%
Pb: ≤0.0005%
Sr: ≤0.0005%
Zn: ≤0.0005%

absorption

≤0.05 at 280 in H2O at 0.1 M
≤0.08 at 260 in H2O at 0.1 M

HLB

40

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

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General description

Sodium dodecyl sulfate (SDS) is a well-known anionic detergent widely used in scientific research to denature proteins′ secondary and tertiary structures. It consists of a 12-carbon non-polar chain with a negatively charged sulfate group at the end. SDS is instrumental in denaturing and solubilizing proteins, making it a fundamental component of procedures like polyacrylamide gel electrophoresis, where it helps determine protein molecular weights.Moreover, SDS acts as an organic sodium salt and serves dual roles as a detergent and a protein denaturant. Its distinctive feature is its anionic surfactant nature, characterized by a negative charge. This charge fosters interactions with proteins and lipids, leading to the creation of micellar structures. These micelles are essential for SDS′s capacity to effectively solubilize and stabilize proteins and lipids, enabling their detailed study and manipulation in scientific research. SDS′s amphipathic properties, stemming from a long-chain aliphatic group with an attached negatively charged sulfate, make it a valuable detergent for various biomolecular experiments and studies.

Application

Sodium dodecyl sulfate has been used as a:
  • surfactant to evaluate cytochrome c affinity by using surface plasmon resonance
  • surfactant in particle enhanced immunoassays to inhibit aggregation of particles and to enhance single microsphere coupling
  • biofilm-disrupting agent

Anionic detergent

Features and Benefits

  • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
  • Tested for trace levels of Anions and Cations
  • High-purity product ideal for biochemical research purposes

Other Notes

For additional information on our range of Biochemicals, please complete this form.

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

338.0 °F

flash_point_c

170 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Lonnie J Lucas et al.
Colloids and surfaces. B, Biointerfaces, 49(2), 106-111 (2006-04-20)
Manufacturers of latex immunoassays have typically added surfactants to improve detection sensitivity and prevent non-specific aggregation of microspheres, which may cause both false positives and negatives during diagnostic testing. There is also growing interest in conducting immunoassays in smaller volumes
Biomedical Devices and Their Applications (2013)
Brandon M Childers et al.
Infection and immunity, 81(11), 4112-4120 (2013-08-28)
Biofilm formation and persistence are essential components for the continued survival of pathogens inside the host and constitute a major contributor to the development of chronic wounds with resistance to antimicrobial compounds. Understanding these processes is crucial for control of
Evaluation of cytochrome c affinity to anionic phospholipids by means of surface plasmon resonance
Stepanov G, et al.
Febs Letters, 583(1), 97-100 (2009)
Lekun Fang et al.
Oncotarget, 5(10), 2974-2987 (2014-06-11)
Colorectal cancer (CRC) is one of the most common cancers worldwide, especially in Western countries. Although chemotherapy is used as an adjuvant or as a palliative treatment, drug resistance poses a great challenge. This study intended to identify biomarkers as

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