05587

Dexrazoxane

analytical standard

• Synonym(s): (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione, (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, Cardioxane, ICRF-187, NSC169780, Zinecard
• Empirical Formula (Hill Notation): C₁₁H₁₆N₄O₄
• CAS Number: 24584-09-6
• Molecular Weight: 268.27
• MDL number: MFCD00866449
• UNSPSC Code: 41116107
• PubChem Substance ID: 329748105
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• assay: ≥97.0% (GC)
• shelf life: limited shelf life, expiry date on the label
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: C[C@@H](CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
• InChI: 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
• InChI key: BMKDZUISNHGIBY-ZETCQYMHSA-N

Description

Biochem/physiol Actions

Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable