Skip to Content
Merck
All Photos(4)

Key Documents

View All Documentation

C9538

Sigma-Aldrich

Coenzyme Q10

≥98% (HPLC), powder, antioxidant

Synonym(s):

CoQ10, Q-10, Ubiquinone 50, Ubiquinone-10

Sign Into View Organizational & Contract Pricing

Select a Size

100 G
€50.20

€50.20

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(4)

Select a Size

Change View
100 G
€50.20

About This Item

Empirical Formula (Hill Notation):
C59H90O4
CAS Number:
303-98-0
Molecular Weight:
863.34
Beilstein/REAXYS Number:
1900141
EC Number:
206-147-9
MDL number:
MFCD00042919
UNSPSC Code:
12352200
PubChem Substance ID:
24893170
NACRES:
NA.77

€50.20

Please contact Customer Service for Availability
Request a Bulk Order

Product Name

Coenzyme Q10, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

yellow to dark orange

mp

49 °C

application(s)

cell analysis

storage temp.

−20°C

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

Looking for similar products? Visit Product Comparison Guide

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
B16003517895493732
1-Phenyl-1,3-butanedione 99%

B11907

1-Phenyl-1,3-butanedione

4-Phenyl-2-butanone 98%

B16003

4-Phenyl-2-butanone

trans-4-Phenyl-3-buten-2-one-1,1,1,3-d4 97 atom % D

517895

trans-4-Phenyl-3-buten-2-one-1,1,1,3-d4

1,4-Butanediol ReagentPlus®, 99%

493732

1,4-Butanediol

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

mp

54-56 °C (lit.)

mp

-

mp

39-42 °C (lit.)

mp

16 °C (lit.)

density

1.09 g/mL at 25 °C (lit.)

density

0.989 g/mL at 25 °C (lit.)

density

-

density

1.017 g/mL at 25 °C (lit.)

form

powder

form

liquid

form

-

form

solid or viscous liquid

General description

Coenzyme Q (CoQ), also known as ubiquinone, is a lipid-soluble antioxidant and is an essential component of the mitochondrial electron transport chain. The molecule contains a biologically active quinone with a benzoquinone ring and an isoprenoid sidechain. Q10 is synthesized in the cytoplasm and mitochondria ([1]) which generates ATP through aerobic cellular respiration. CoQ10 is required for the optimal functioning of the immune system and for cardiovascular health ([2]). The ability to repress inflammatory gene expression exhibits its anti-inflammatory property ([3] ) Genetic failure or ageing results in CoQ10 deficiency, indicated by suppression of immune function. ([1])

Application

Coenzyme Q10 (CoQ10) has been used:
  • as a bioactive compound to study its immune modulating properties in vitro[4]
  • as a standard for high-performance liquid chromatography[5][6]
  • to study its effect on exercised rat aorta[7]
  • in the cellular CoQ uptake assay[8]

Biochem/physiol Actions

Coenzyme Q10 is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP.[5]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCL3912
    SLCK0119
    SLCF9505
    SLCB9480
    SLBX4909

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Courtney M Anderson et al.
    Cell reports, 10(4), 505-515 (2015-01-27)
    Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthesize CoQ mostly endogenously, exogenous supplementation with
    N Okudan et al.
    Acta physiologica Hungarica, 99(1), 40-50 (2012-03-20)
    In this study, the effect of long-term supplementation of coenzyme Q10 (CoQ10) on the responses of swim-trained rat aorta was investigated. Twenty-four adult male Wistar rats were divided into four groups: untrained, trained, untrained+CoQ10, and trained+CoQ10 group. In the trained
    E L Appelkvist et al.
    The Clinical investigator, 71(8 Suppl), S97-102 (1993-01-01)
    Inhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density lipoprotein cholesterol in hypercholesterolemic patients. However, little is known about the possible effects of these inhibitors on dolichol and cholesterol synthesis. Oral administration of mevinolin
    Lionel Van Maldergem et al.
    Annals of neurology, 52(6), 750-754 (2002-11-26)
    A 31-year-old woman had encephalopathy, growth retardation, infantilism, ataxia, deafness, lactic acidosis, and increased signals of caudate and putamen on brain magnetic resonance imaging. Muscle biochemistry showed succinate:cytochrome c oxidoreductase (complex II-III) deficiency. Both clinical and biochemical abnormalities improved remarkably
    Steven Lunetta et al.
    Journal of AOAC International, 91(4), 702-708 (2008-08-30)
    An international collaborative study was conducted of a high-performance liquid chromatographic (HPLC)-UV method for the determination of coenzyme Q10 (CoQ10, ubidecarenone) in raw materials and dietary supplements. Ten collaborating laboratories determined the total CoQ10 content in 8 blind duplicate samples.
    View All Related Papers

    Articles

    Electron Transport

    Learn about the four membrane-bound protein complexes that make up the electron transport chain metabolic pathway supplying energy as ATP for cellular respiration.

    Dietary Antioxidants

    Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

    Related Content

    Discover Bioactive Small Molecules for Lipid Signaling Research

    Discover Bioactive Small Molecules for Lipid Signaling Research

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service