Pharmaceutical Secondary Standard; Certified Reference Material

Methyl 4-hydroxybenzoate, NIPAGIN, p-Hydroxybenzoic acid methyl ester, Methyl paraben
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:
E Number:

Quality Level


certified reference material
pharmaceutical secondary standard




current certificate can be downloaded


HPLC: suitable
gas chromatography (GC): suitable


125-128 °C (lit.)

Featured Industry

Cleaning Products
Flavors and Fragrances
Food and Beverages
Personal Care
Pharmaceutical (small molecule)



pharmacopeia traceability

traceable to PhEur M1650000
traceable to USP 1432005

SMILES string




InChI key


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General description

Methylparaben is an antifungal and antibacterial agent, widely used as a preservative in cosmetics, pharmaceuticals, food and beverages.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.


These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Methylparaben may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase sequential injection chromatography (SIC) technique and high-performance liquid chromatography technique.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.


To see an example of a Certificate of Analysis for this material enter LRAC0280 in the slot below. This is an example certificate only and may not be the lot that you receive.



Hazard Statements

Precautionary Statements


NONH for all modes of transport

WGK Germany


Flash Point(F)

334.4 °F

Flash Point(C)

168 °C

Certificate of Analysis

Certificate of Origin

A novel gradient HPLC method for simultaneous determination of ranitidine, methylparaben and propylparaben in oral liquid pharmaceutical formulation
Kokoletsi XM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 38(4), 763-767 (2005)
Determination of ambroxol hydrochloride, methylparaben and benzoic acid in pharmaceutical preparations based on sequential injection technique coupled with monolithic column
Satinsky D, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(2), 287-293 (2006)
Simultaneous determination of methylparaben, propylparaben, hydrocortisone acetate and its degradation products in a topical cream by RP-HPLC.
Hajkova R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 32(4-5), 921-927 (2003)
K Kannathasan et al.
Acta tropica, 120(1-2), 115-118 (2011-07-19)
The vector-borne diseases caused by mosquitoes are one of the major health problems in many countries especially in tropical and sub-tropical countries. The resistance of mosquitoes to synthetic chemicals and environmental toxicity created by the chemicals raised the demand for...
Ismail I Hewala et al.
Talanta, 88, 623-630 (2012-01-24)
Simple methods for HPTLC peak purity assessment and identification of the HPTLC peaks were presented. The spectrodensitograms - selected at different time intervals across the elution time of the HPTLC peak - were extracted and digital algorithms for manipulating the...
Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard
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