PHR1010

Supelco

Propylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Propyl paraben, Propyl 4-hydroxybenzoate, 4-Hydroxybenzoic acid propyl ester
Linear Formula:
HOC6H4CO2CH2CH2CH3
CAS Number:
Molecular Weight:
180.20
Beilstein/REAXYS Number:
1103245
EC Number:
MDL number:
PubChem Substance ID:
E Number:
E216
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

form

neat

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

95-98 °C (lit.)

Featured Industry

Cleaning Products
Cosmetics
Food and Beverages
Personal Care
Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to PhEur P3650000
traceable to USP 1577008

SMILES string

CCCOC(=O)c1ccc(O)cc1

InChI

1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

InChI key

QELSKZZBTMNZEB-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Propylparaben is the benzoate ester, widely used as a preservative in personal care products.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2080 in the slot below. This is an example certificate only and may not be the lot that you receive.

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 1

Flash Point(F)

356.0 °F

Flash Point(C)

180 °C

Certificate of Analysis

Certificate of Origin

Hye-Min Kang et al.
Chemosphere, 226, 388-394 (2019-04-05)
Parabens are used as a preservative substance in a wide range of man-made products causing deleterious effects on aquatic organisms and therefore, the concern of their effects to aquatic organisms has been increased. In this study, acute toxicity of methylparaben...
O Herrero et al.
Mutation research, 743(1-2), 20-24 (2012-01-18)
Di(2-ethylhexyl)phthalate, triclosan and propylparaben are contaminants of emerging concern that have been subjected to extensive toxicological studies, but for which limited information is currently available concerning adverse effects on terrestrial plant systems. The Allium cepa test, which is considered one...
Michelle P Dvores et al.
Langmuir : the ACS journal of surfaces and colloids, 28(17), 6978-6984 (2012-03-29)
This study presents a method for one-step formation of poly(ethylene oxide) nanofibers incorporating nanoparticles of a poorly water-soluble compound. Using the new method reported here, nanofiber-nanoparticle composites are fabricated in one step by electrospinning of an oil-in-water microemulsion, in which...
Dennis G Maki et al.
Critical care medicine, 39(4), 613-620 (2011-01-05)
Catheter-related bloodstream infection is the greatest threat to the safety of patients on hemodialysis. Catheter lock solutions containing heparin have been linked to an increased risk of hemorrhage and thrombocytopenia. To ascertain the safety and efficacy for prevention of catheter-related...
Aeshna Amin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 75(2), 206-212 (2010-03-09)
p-Hydroxybenzoic acid esters (parabens) are commonly used antimicrobial preservatives in pharmaceutical formulations. Two microorganisms, isolated from non-sterile methyl paraben (MP) and propyl paraben (PP) solutions, were found to degrade the respective parabens. Identification by 16S rRNA partial gene sequencing revealed...
Protocols
Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard
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