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Methyl Paraben

PESTANAL®, analytical standard

Methyl 4-hydroxybenzoate, NIPAGIN, p-Hydroxybenzoic acid methyl ester, Methyl paraben
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:
E Number:

Quality Level


analytical standard

product line





current certificate can be downloaded


ampule of 1000 mg


HPLC: suitable
gas chromatography (GC): suitable


125-128 °C (lit.)

Featured Industry

Cleaning Products
Food and Beverages
Personal Care



storage temp.

room temp

SMILES string




InChI key


Gene Information

rat ... Ar(24208)

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General description

Methyl paraben is basically a methyl ester of p-hydroxybenzoic acid. It is non-toxic, and non-carcinogenic in nature. It is a stable, non-volatile compound and finds application as an anti-microbial preservative in foods, drugs and cosmetics. It is readily absorbed through the skin and gastrointestinal tract. Upon hydrolyzation, it is hydrolyzed to p-hydroxybenzoic acid, and the conjugates formed get rapidly excreted in the urine.
Methyl Paraben is a stable, non-volatile, methyl ester of p-hydroxybenzoic acid. It can find applications as a broad-spectrum antimicrobial preservative in foods, drugs and cosmetics. It is found to be noncarcinogenic and is highly effective against fungi like molds and yeast as well as bacteria.


Methyl paraben was used a preservative standard in commercial food products, during an experimental investigation, done to study the application of microemulsion electrokinetic chromatography (MEEKC), in detecting food preservatives.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH



Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

334.4 °F

Flash Point(C)

168 °C

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How is Product No. 47889 EPA 8040A Phenol Calibration Mix packaged?

    Product No. 47889 comes packaged in a 4ml amber vial with teflon lined solid cap.

  4. What is Product No. 47889 EPA 8040A Phenol Calibration Mix soluble in?

    Product No. 47889 EPA 8040A Phenol Calibration Mix is slightly soluble in water and soluble in alcohol, diethyl ether, and acetone

  5. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  6. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  7. My question is not addressed here, how can I contact Technical Service for assistance?

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Combined activation of methyl paraben by light irradiation and esterase metabolism toward oxidative DNA damage
Okamoto Y, et al.
Chemical Research in Toxicology, 21, 1594-1599 (2008)
Application of microemulsion electrokinetic chromatography for the detection of preservatives in foods.
Huang H.y
Food Chemistry, 89 (2), 315-322 (2005)
Evaluation of the health aspects of methyl paraben: a review of the published literature.
Soni MG
Food And Chemical Toxicology, 40 (10), 1335-1373 (2002)
Evaluation of the health aspects of methyl paraben: a review of the published literature
Soni.G.M, et al.
Food And Chemical Toxicology, 40, 1335-1373 (2002)
K Kannathasan et al.
Acta tropica, 120(1-2), 115-118 (2011-07-19)
The vector-borne diseases caused by mosquitoes are one of the major health problems in many countries especially in tropical and sub-tropical countries. The resistance of mosquitoes to synthetic chemicals and environmental toxicity created by the chemicals raised the demand for...


HPLC analysis of Methyl Paraben and Organic Acids on Ascentis® Express RP-Amide

Separation of Uracil; p-Aminobenzoic acid; Acetylsalicylic acid; Dehydroacetic acid; Benzoic acid; Methyl paraben; 3-Fluorobenzoic acid

HPLC Analysis of Paraben Preservatives on Discovery® C18

Separation of Methyl Paraben, analytical standard; Ethylparaben, United States Pharmacopeia (USP) Reference Standard; Propylparaben, United States Pharmacopeia (USP) Reference Standard; Butylparaben, United States Pharmacopeia (USP) Reference Standard

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