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Key Documents
X2252
Xanthine Oxidase microbial
lyophilized powder, ≥7 units/mg solid
Synonim(y):
Schardingerenzyme, XO, hypoxanthine oxidase, XOD, Xanthine:oxygen oxidoreductase
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About This Item
Polecane produkty
pochodzenie biologiczne
microbial
Poziom jakości
Postać
lyophilized powder
aktywność właściwa
≥7 units/mg solid
masa cząsteczkowa
~160 kDa
metody
inhibition assay: suitable
kolor
brown
optymalne pH
7.5-8.0
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
Escherichia coli K12 ... xdhA(947116) , xdhB(947205) , xdhC(945148)
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Opis ogólny
Research area: Cell Cycle
Xanthine Oxidase (XO), a versatile molybdoflavoprotein, is one of the forms of xanthine oxidoreductases (XORs). XO is characterized with two flavin molecules (FAD), two molybdenum atoms, and eight iron atoms bound per enzymatic unit.
Xanthine Oxidase (XO), a versatile molybdoflavoprotein, is one of the forms of xanthine oxidoreductases (XORs). XO is characterized with two flavin molecules (FAD), two molybdenum atoms, and eight iron atoms bound per enzymatic unit.
Zastosowanie
Xanthine Oxidase microbial has been used:
- to determine in vitro xanthine oxidase activity
- as a source to generate superoxide anions during superoxide dismutase assay
- as a component of the reagent mix in colorimetric paper-based device to detect allopurinol in traditional medicine by enzymatic reaction
Działania biochem./fizjol.
Xanthine Oxidase catalyzes the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid and oxygen free radicals during purine metabolism. This enzyme is also implicated in caffeine metabolism. XO also plays a vital role in the catabolism of xenobiotics including various drugs such as thiopurine drugs, containing 6-mercaptopurine, allopurinol, and uric acid. Excess of XO activity causes hyperuricemia (higher levels of uric acid in the blood), which further leads to gout.
Also contains proteolytic activity.
Właściwości fizyczne
Inhibitors: Reducing agents, Hg++, Ag+,MIA
Optimum pH: 7.5 - 8.0
Optimum temperature: 65oC
pH Stability: pH 6.5 - 9.0 (25oC, 15hr)
Thermal stability: below 55oC (pH 8.0, 30min)
Optimum pH: 7.5 - 8.0
Optimum temperature: 65oC
pH Stability: pH 6.5 - 9.0 (25oC, 15hr)
Thermal stability: below 55oC (pH 8.0, 30min)
Definicja jednostki
One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.
Postać fizyczna
Lyophilized powder containing BSA and sodium glutamate as stabilizers
Przechowywanie i stabilność
Tightly closed. Dry. Keep locked up or in an area accessible only to qualified or authorized
persons
persons
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inhibitor
Numer produktu
Opis
Cennik
Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Resp. Sens. 1
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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Pál Pacher et al.
Pharmacological reviews, 58(1), 87-114 (2006-03-02)
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Protokoły
The appearance of uric acid is measured at 293nm by spectrophotometry.
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