SRP3017
BMP-6 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture
Synonim(y):
VGR
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About This Item
Kod UNSPSC:
12352202
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
rekombinowane
expressed in HEK 293 cells
Próba
≥95% (HPLC)
≥95% (SDS-PAGE)
Formularz
lyophilized
siła działania
0.03-0.06 μg/mL ED50
masa cząsteczkowa
26.2 kDa
opakowanie
pkg of 10 μg
metody
cell culture | mammalian: suitable
zanieczyszczenia
<0.1 EU/μg endotoxin, tested
numer dostępu UniProt
Warunki transportu
wet ice
temp. przechowywania
−20°C
informacje o genach
human ... BMP6(654)
Opis ogólny
BMP6 (bone morphogenetic protein 6) is one of the BMPs which are secreted signaling proteins belonging to the transforming growth factor-β (TGF-β) superfamily. This gene is localized to human chromosome 6p24.1.
Recombinant human BMP-6 is a 26.2kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Recombinant human BMP-6 is a 26.2kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Działania biochem./fizjol.
BMPs (bone morphogenetic proteins) were initially identified from demineralized bone extracts capable of stimulating endochondral osteogenesis at extraskeletal sites in vivo. BMP6 is thought to be involved in early embryogenesis. In hepatocellular carcinoma (HCC) the expression of this protein is suppressed due to hypermethylation, and this is linked with poor patient outcomes. This protein is also down-regulated due to CpG island methylation in CRC (colorectal carcinoma), although it is not yet been found to be linked with tumor progression or prognosis. BMP6 is involved in chondrocyte differentiation, and in fetal kidney and urinary system development. It is thought to be involved in ovulation, where it elevates the accumulation of neutrophils in ovulatory follicles and reduces the influence of protease inhibitors.
Sekwencja
VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
Postać fizyczna
Lyophilized from 10 mM Tris, pH 9.0.
Rekonstytucja
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Hypermethylation leads to bone morphogenetic protein 6 downregulation in hepatocellular carcinoma.
He Y et al
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The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary.
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Expression of BMP6 is associated with its methylation status in colorectal cancer tissue but lacks prognostic significance.
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Asian Pacific Journal of Cancer Prevention, 15(17), 7091-7095 (2014)
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