X3004

XAV939

≥98% (HPLC), powder, tankyrase inhibitor

• Synonim(y): 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
• Wzór empiryczny (zapis Hilla): C₁₄H₁₁F₃N₂OS
• Numer CAS: 284028-89-3
• Masa cząsteczkowa: 312.31
• Numer MDL: MFCD16879017
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329830802
• NACRES: NA.77

Właściwości

• product name: XAV939, ≥98% (HPLC)
• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: powder
• kolor: white to beige
• rozpuszczalność: DMSO: 5 mg/mL, clear
• temp. przechowywania: room temp
• ciąg SMILES: FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
• InChI: 1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
• Klucz InChI: KLGQSVMIPOVQAX-UHFFFAOYSA-N

Opis

Zastosowanie

XAV939 has been used in the inhibition

• of tankyrase in neuroblastoma cell lines
• of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells
• of wnt signalling in human induced pluripotent stem cells (hiPSCs)

Działania biochem./fizjol.

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)

Cechy i korzyści

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Inne uwagi

XAV939 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XAV939 probe summary on the Chemical Probes Portal website.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P312 - P501
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable