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Kluczowe dokumenty
SML0559
LDN193189 hydrochloride
≥98% (HPLC), powder, ALK2/3 inhibitor
Synonim(y):
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride, DM-3189
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About This Item
Wzór empiryczny (zapis Hilla):
C25H22N6 · xHCl
Numer CAS:
Masa cząsteczkowa:
406.48 (free base basis)
Numer MDL:
Kod UNSPSC:
51111800
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Nazwa produktu
LDN193189 hydrochloride, ≥98% (HPLC)
Poziom jakości
Próba
≥98% (HPLC)
Formularz
powder
warunki przechowywania
desiccated
kolor
yellow to orange
rozpuszczalność
H2O: 5 mg/mL, clear (warmed)
Warunki transportu
wet ice
temp. przechowywania
−20°C
ciąg SMILES
C(C=N1)(C2=CC=C(N3CCNCC3)C=C2)=CN4C1=C(C5=CC=NC6=C5C=CC=C6)C=N4.Cl
InChI
1S/C25H22N6.ClH/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30;/h1-10,15-17,26H,11-14H2;1H
Klucz InChI
PCCDKTWDGDFRME-UHFFFAOYSA-N
Zastosowanie
LDN193189 hydrochloride has been used as an ALK2/3 (type I receptor serine-threonine kinases) inhibitor, to study the effect of TGFβ1/2/3 (tumor growth factor β) and BMP (bone morphogenetic protein) signaling on spinal cord development in zebrafish. It has also been used to inhibit SMAD (homologues of the Drosophila protein, mothers against decapentaplegic), in order to prevent non neuronal differentiation.
Działania biochem./fizjol.
Although LDN193189 is a structural analog of dorsomorphin, these two drugs are found to establish different cellular responses. In vitro analysis reveals that LDN193189 inhibits a number of intracellular kinases such as, mitogen activated protein kinase 14 and 8 ( p38and c-Jun N-terminal kinase respectively), as well as those associated with AKT (serine/threonine kinase) and mTOR (mammalian target of rapamycin) signaling mechanisms. LDN193189 is known to elevate the levels hemoglobin and thus helps to prevent the onset of anemia of inflammation.
LDN193189 is a derivative of dorsomorphin that is a highly selective antagonist of BMP receptor isotypes ALK2 and ALK3 (IC50 of: 5 and 30 nM). The selectivity of LDN193189 for ALK2/3 is 200 fold over the TGF-B type receptors ALK4,-5 and -7. In murine smooth muscle cells, the compound inhibits BMP-4 induced phosphorylation of SMAD 1/5/8 with an IC50 of 5 nM.
LDN193189 is a selective BMP receptor antagonist.
Uwaga dotycząca przygotowania
Produkt jest rozpuszczalny w wodzie w stężeniu co najmniej 5 mg/ml.
Ta strona może zawierać tekst przetłumaczony maszynowo.
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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