I7378

Indomethacin

98.5-100.5% (in accordance with EP), powder or crystals, COX inhibitor

• Synonim(y): 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid
• Wzór empiryczny (zapis Hilla): C₁₉H₁₆ClNO₄
• Numer CAS: 53-86-1
• Masa cząsteczkowa: 357.79
• Beilstein: 497341
• Numer WE: 200-186-5
• Numer MDL: MFCD00057095
• Kod UNSPSC: 12161501
• Identyfikator substancji w PubChem: 24278173
• NACRES: NA.77

Właściwości

• product name: Indomethacin, 98.5-100.5% (in accordance with EP)
• pochodzenie biologiczne: synthetic
• Poziom jakości: 200
• Próba: 98.5-100.5% (in accordance with EP)
• Postać: powder or crystals
• strata: ≤0.5% loss on drying
• mp: 158-162 °C
• Tryb działania: enzyme | inhibits
• ciąg SMILES: COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
• InChI: 1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
• Klucz InChI: CGIGDMFJXJATDK-UHFFFAOYSA-N
• informacje o genach: human ... ALB(213) , ALOX5(240) , ELA2(1991) , GPR44(11251) , IL1A(3552) , PLA2G1B(5319) , PTGDR(5729) , PTGS1(5742) , PTGS2(5743) ; mouse ... Alox5(11689) , Ptgdr(19214) , Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219) , Ptgs1(19224) ; rat ... Alox5(25290) , Ptgs1(24693) , Ptgs2(29527)

Opis

Opis ogólny

Indomethacin is an inhibitor of the enzyme cyclooxygenase 1 and 2. Indomethacin elicits side effects in gastrointestinal tract, kidney and cerebrum. Indomethacin, along with ibuprofen, is effective for treating patent ductus arteriosus (PDA) in infants with respiratory distress syndrome. Rectal indomethacin is effective in treating endoscopic retrograde cholangiography (ERCP) induced pancreatitis.

Zastosowanie

Indomethacin has been used:

• as a medium supplement in osteogenic and adipogenic differentiation assays in human bone marrow stem cells
• as a medium supplement in bovine amniotic fluid stem cells (BAFSCs) culture
• in the inhibition of prostaglandin E2 (PGE2) in T cells

Działania biochem./fizjol.

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.

Cechy i korzyści

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H300
• Zwroty wskazujące środki ostrożności: P264 - P270 - P301 + P310 - P405 - P501
• Klasyfikacja zagrożeń: Acute Tox. 1 Oral
• Kod klasy składowania: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges