SML0305

3-Deazaneplanocin A hydrochloride

≥97% (HPLC)

• Synonim(y): (-)-1-[(1R,4R,5S)-3-(Hydroxymethyl)-4,5-dihydroxy-2-cyclopenten-1-yl]4-aminoimidazo[4,5-c]pyridine hydrochloride, DZNep hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₁₄N₄O₃ · HCl
• Numer CAS: 120964-45-6
• Masa cząsteczkowa: 298.73
• Numer MDL: MFCD18782644
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329825310
• NACRES: NA.77

Właściwości

• Próba: ≥97% (HPLC)
• Formularz: powder
• aktywność optyczna: [α]/D -88 to -108°, c = 0.1 in water
• warunki przechowywania: desiccated
• kolor: white to beige
• rozpuszczalność: H₂O: ≥5 mg/mL
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• ciąg SMILES: Cl.Nc1nccc2n(cnc12)[C@@H]3C=C(CO)[C@@H](O)[C@H]3O
• InChI: 1S/C12H14N4O3.ClH/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19;/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14);1H/t8-,10-,11+;/m1./s1
• Klucz InChI: UNSKMHKAFPRFTI-FDKLLANESA-N

Opis

Opis ogólny

3-Deazaneplanocin A hydrochloride is a carbocyclic analog of adenosine. It has antimetastatic property. It is used to treat Ebola virus disease, gastric cancer, myeloma and lymphoma.

Zastosowanie

3-Deazaneplanocin A hydrochloride has been used to examine the potential involvement of autophagy and apoptosis in colorectal cancer (CRC) cells.

3-Deazaneplanocin A hydrochloride has been used to test its effect on ovarian tumor progression. It has also been used as a S-adenosyl homocysteine hydrolase (SAH) inhibitor in c33A2 cells.

Działania biochem./fizjol.

3-Deazaneplanocin A (DZNep) is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor. It switches on repressed tumor suppressor genes and induces apoptosis by inhibiting the expression of EZH2.

3-Deazaneplanocin A is an S-Adenosylhomocysteine Hydrolase inhibitor and histone methyltransferase EZH2 inhibitor.

Cechy i korzyści

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable