P9297

Paromomycin sulfate salt

≥98% (TLC)

• Synonim(y): Siarczan aminozydyny
• Wzór empiryczny (zapis Hilla): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• Numer CAS: 1263-89-4
• Masa cząsteczkowa: 615.63 (free base basis)
• Beilstein: 5715182
• Kod UNSPSC: 51281663
• Identyfikator substancji w PubChem: 24278662
• NACRES: NA.85

Właściwości

• Poziom jakości: 200
• Próba: ≥98% (TLC)
• Formularz: powder
• spektrum działania antybiotyku: Gram-negative bacteria; Gram-positive bacteria; parasites
• Tryb działania: protein synthesis | interferes
• ciąg SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C
• InChI: 1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1
• Klucz InChI: OYJABWUHUYVDMJ-UDXJMMFXSA-N

Opis

Opis ogólny

Chemical structure: aminoglycoside

Zastosowanie

Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. It has in vitro and in vivo activity similar to neomycin. It is effective against Gram-negative bacteria, Gram-positive bacteria, some protozoan species, and limited antihelminth.
It is used to study bacterial protein synthesis at the level of 16S ribosomal RNA and 30S ribosome assembly. Paromomycin is used to study cytosine-cytosine (CC) mismatch-containing RNA molecules and is used to inhibit Cryptosporidium infection of a human enterocyte cell line.

Działania biochem./fizjol.

Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth.
Mode of Action: Inhibits initiation and elongation during protein synthesis.

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Opakowanie

1g,5g,25g

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable