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AP113P

Sigma-Aldrich

Goat Anti-Human IgG Antibody, Fc, HRP conjugate

Chemicon®, from goat

Synonim(y):

Anti-Human IgG HRP, Goat Anti-Human IgG

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.46

pochodzenie biologiczne

goat

Poziom jakości

100

białko sprzężone

peroxidase conjugate

forma przeciwciała

F(ab′)2 fragment of affinity isolated antibody

rodzaj przeciwciała

secondary antibodies

klon

polyclonal

reaktywność gatunkowa

human

producent / nazwa handlowa

Chemicon®

metody

ELISA: suitable
western blot: suitable

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

Opis ogólny

Immunoglobulin G (IgG) is the most common antibody isotype found in the human serum. It exists in four isotypes IgG1, IgG2, IgG3, and IgG4. IgG structure is characterized with four polypeptide chains with two identical heavy (H) chains and two identical λ light (L) chains. These chains are inter-linked by disulfide bonds. IgG is produced by the B cells.

Immunogen

Human IgG

Zastosowanie

Goat Anti-Human IgG Antibody, Fc, HRP conjugate has been used in enzyme linked immunosorbent assay (ELISA)(1:3,000).
It is also suitable for use in:
  • enzyme immunoassay (EIA) with OPD: 1:5,000-1:100,000
  • immunohistochemistry 1:500-1:5,000
  • western blot

Działania biochem./fizjol.

Immunoglobulin G (IgG) is implicated in antibody-dependent cell-mediated cytotoxicity (ADCC). It aids in the activation of the classical pathway of the complement system. It neutralizes virus particles and toxins. Maternal IgG is transferred to the fetus through the placenta that is crucial for protecting newborns against infectious diseases. Measurement of IgG levels in severe acute respiratory syndrome coronavirus (SARS‐CoV)‐2 infected patients can be used as a potential strategy to assess the severity and prognosis of coronavirus disease 2019 (COVID‐19).

Postać fizyczna

Lyophilized. Buffer = 0.01 M Sodium Phosphate, 0.25 M NaCl, pH 7.6 with 15 mg/mL BSA. Contains no preservative.

Informacje prawne

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

Sally Esmail et al.
Cell reports methods, 1(2), 100011-100011 (2021-07-09)
We have developed a rapid, accurate, and cost-effective serologic test for SARS-CoV-2 virus, which caused the COVID-19 pandemic, on the basis of antibody-dependent agglutination of antigen-coated latex particles. When validated using plasma samples that are positive or negative for SARS-CoV-2
PCSK9 prosegment chimera as novel inhibitors of LDLR degradation.
Saavedra, YG; Zhang, J; Seidah, NG
Testing null
Tara Bancroft et al.
Cellular immunology, 304-305, 35-43 (2016-05-24)
The recent increase in cases of whooping cough among teenagers in the US suggests that the acellular Bordetella pertussis vaccine (aP) that became standard in the mid 1990s might be relatively less effective than the whole-bacteria formulation (wP) previously used
Dorothee Winterberg et al.
Journal of clinical medicine, 10(12) (2021-07-03)
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most frequent malignancy in children and also occurs in adulthood. Despite high cure rates, BCP-ALL chemotherapy can be highly toxic. This type of toxicity can most likely be reduced by antibody-based immunotherapy
Courtney Voss et al.
JCI insight, 6(13) (2021-06-04)
BACKGROUNDThe role of humoral immunity in COVID-19 is not fully understood, owing, in large part, to the complexity of antibodies produced in response to the SARS-CoV-2 infection. There is a pressing need for serology tests to assess patient-specific antibody response
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