O4375

Oxytocin

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

• Synonim(y): α-Hypophamine, Oxytocic hormone
• Wzór empiryczny (zapis Hilla): C₄₃H₆₆N₁₂O₁₂S₂
• Numer CAS: 50-56-6
• Masa cząsteczkowa: 1007.19
• Beilstein: 3586108
• Numer MDL: MFCD00076731
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 24897994
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: synthetic
• Poziom jakości: 200
• sterylność: non-sterile
• Formularz: lyophilized powder
• aktywność właściwa: ~15 IU/mg solid (Prepared from synthetic oxytocin)
• rozpuszczalność: water: 10 mg/mL, clear, colorless
• numer dostępu UniProt: P01178; P30559; P70536
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
• InChI: 1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
• Klucz InChI: XNOPRXBHLZRZKH-DSZYJQQASA-N
• informacje o genach: human ... OXT(5020) , OXTR(5021) ; rat ... Oxtr(25342)

Opis

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

Opis ogólny

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Zastosowanie

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.

Działania biochem./fizjol.

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.

Postać fizyczna

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable