O3251

Oxytocin

• Synonim(y): α-Hypophamine, Oxytocic hormone
• Wzór empiryczny (zapis Hilla): C₄₃H₆₆N₁₂O₁₂S₂
• Numer CAS: 50-56-6
• Masa cząsteczkowa: 1007.19
• Beilstein: 3586108
• Numer WE: 200-048-4
• Numer MDL: MFCD00076731
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 24897975
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: synthetic (organic)
• sterylność: non-sterile
• Próba: ≥97% (HPLC)
• Formularz: lyophilized powder
• numer dostępu UniProt: P01178; P30559; P70536
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O
• InChI: 1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
• Klucz InChI: XNOPRXBHLZRZKH-DSZYJQQASA-N
• informacje o genach: human ... OXT(5020) , OXTR(5021) ; rat ... Oxtr(25342)

Opis

Amino Acid Sequence

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]

Opis ogólny

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Zastosowanie

Oxytocin has been used in experimental study to induce uterine contractions in rats. It has been used in comet assay to determine the number of cells with DNA damage.

Działania biochem./fizjol.

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.

Postać fizyczna

Supplied as a powder with a peptide content of ≥ 75%

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable