O3514

Bovine Osteopontin

from bovine milk, powder, suitable for cell culture

• Synonim(y): Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)
• Numer MDL: MFCD03100698
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• product name: Osteopontin from bovine milk, lyophilized powder
• pochodzenie biologiczne: bovine milk
• Poziom jakości: 100
• sterylność: sterile
• Postać: lyophilized powder
• masa cząsteczkowa: ~60 kDa
• opakowanie: pkg of 50 μg
• metody: cell culture | mammalian: suitable
• numer dostępu UniProt: P31098; P31096
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• informacje o genach: cow ... SPP1(281499)

Opis

Opis ogólny

Osteopontin (OPN) is a multifunctional protein. It is released by macrophages, T cells and epithelial cells. It has 261 amino acid residues with a molecular mass of 29,283 Da. Osteopontin is also called as uropontin. Osteopontin from bovine milk is highly glycosylated and phosphorylated. SPP1 gene (secreted phosphoprotein 1) codes for osteopontin. This gene is located on human chromosome 4 and cow chromosome 6. It has seven exons and six introns.

Działania biochem./fizjol.

A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity.

Osteopontin stimulates cell mediated responses, chemotaxis of inflammatory cells and anti-inflammatory responses. It binds to av-containing integrins and stimulate cell adhesion and migration. Osteopontin promotes Th1 type immunity.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Komentarz do analizy

The biological activity is measured by its ability to mediate 293 cell adhesion.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)