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Merck

O4264

Sigma-Aldrich

Human Osteopontin

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonim(y):

Bone Sialoprotein-1, Early T Lymphocyte Activation Protein-1 (ETA-1), OPN, Secreted Phosphoprotein 1 (Spp1)

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About This Item

Numer MDL:
Kod UNSPSC:
12352202
NACRES:
NA.32

product name

Osteopontin human, recombinant, expressed in NSO cells, ≥95% (SDS-PAGE), lyophilized powder, suitable for cell culture

pochodzenie biologiczne

human

Poziom jakości

rekombinowane

expressed in NSO cells

sterylność

sterile

Próba

≥95% (SDS-PAGE)

Postać

lyophilized powder

masa cząsteczkowa

60-65 kDa by SDS-PAGE (reducing)

opakowanie

pkg of 50 μg

metody

cell culture | mammalian: suitable

zanieczyszczenia

endotoxin, tested

numer dostępu UniProt

Warunki transportu

ambient

temp. przechowywania

−20°C

informacje o genach

human ... SPP1(6696)

Opis ogólny

Secreted phosphoprotein 1 (SPP1) or osteopontin is a secreted cytokine. This phosphorylated acidic glycoprotein is expressed in various cells and tissues. It is synthesized by osteoblasts. The gene encoding SPP1 is localized on human chromosome 4q22.1.

Zastosowanie

Anti-Osteopontin antibody produced in rabbit has been used for ELISA.

Działania biochem./fizjol.

A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity. Secreted phosphoprotein 1 (SPP1) or osteopontin modulates inflammatory responses and glucose metabolism. It is a chemotactic factor and has a role in immune cell recruitment. The protein is also associated with cell growth, migration and differentiation. SPP1 attaches osteoclasts to the bone matrix. It is also involved in atherosclerotic process and bone mineralization. It is a marker of many cancers.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.

Komentarz do analizy

The biological activity is measured by its ability to mediate 293 cell adhesion.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


Certyfikaty analizy (CoA)

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients
Danny TM
PLoS ONE (2016)
Expanded comparative mapping between man
and rabbit and detection of a new conserved
segment between HSA22 and OCU4
C Chantry
Cytogenetic and genome research (2005)
Polycystic ovary syndrome is associated with increased osteopontin levels
European Journal of Endocrinology (2015)
Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics
Anele Gela
PLoS ONE (2016)
Osteopontin-a possible anchor of osteoclasts to bone
FINN P. REINHOLT
Proceedings of the National Academy of Sciences of the USA (1990)

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