N6009
Nerve Growth Factor-2.5S from murine submaxillary gland
lyophilized powder, suitable for cell culture
Synonim(y):
NGF-2.5S
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About This Item
Polecane produkty
Nazwa produktu
Nerve Growth Factor-2.5S from murine submaxillary gland, NGF-2.5S, lyophilized powder, suitable for cell culture
pochodzenie biologiczne
mouse
Poziom jakości
Formularz
lyophilized powder
siła działania
0.1-30 ng/mL EC50 (using PC-12 cells)
masa cząsteczkowa
26.5 kDa
opakowanie
pkg of 4X25 μg
warunki przechowywania
avoid repeated freeze/thaw cycles
metody
cell culture | mammalian: suitable
numer dostępu UniProt
Warunki transportu
dry ice
temp. przechowywania
−20°C
informacje o genach
mouse ... Ngf(18049)
Opis ogólny
Nerve growth factor (NGF) is produced by different cell types: structural, accessory, and immune cells. It belongs to the neurotrophin family of trophic factors.
Zastosowanie
Nerve Growth Factor-2.5S from murine submaxillary gland has been used:
- in Ham′s F-12 medium for performing growth cone collapse assay using dorsal root ganglions (DRGs)
- as a media supplement in the “process compartment” for microfluidic chamber studies
- to treat mid-luteal cells to study its effect on choline acetyltransferase (CHAT) expression
Działania biochem./fizjol.
Nerve growth factor (NGF) is neurotrophic and maintains sympathetic and sensory neurons of the peripheral nervous system and forebrain cholinergic neurons. NGF promotes the development of neurite-like filaments from chick embryo dorsal root ganglia and rat PC12 pheochromocytoma cells. NGF may have a role in in vivo fetal development and nerve regeneration especially, after ischemic, surgical, or chemical injuries. NGF may also be associated with the central nervous system. It exhibits ameliorating effects against ulcers (human cutaneous, corneal ulcers, and pressure ulcers), glaucoma, maculopathy, and retinitis pigmentosa. NGF-2.5S is a type of NGF-b originally derived under dissociative conditions and often varies from NGF-b due to proteolysis arising during its purification.
Inne uwagi
2.5S subunit of nerve growth factor-7S (NGF-7S) is essentially the β-subunit when isolated from male mouse submaxillary glands under initially dissociative conditions by a modification of the method of Bocchini and Angeletti.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution in sodium acetate buffer.
Komentarz do analizy
The biological activity is measured using a 3-day MTT assay.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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