N0513
Nerve Growth Factor-7S from murine submaxillary gland
NGF-7S, lyophilized powder, suitable for cell culture
Synonim(y):
NGF-7S
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About This Item
Polecane produkty
pochodzenie biologiczne
mouse
Postać
lyophilized powder
siła działania
2-250 ng/mL ED50/EC50
jakość
endotoxin tested
masa cząsteczkowa
protein 130 kDa
opakowanie
pkg of 0.1 mg
metody
cell culture | mammalian: suitable
zanieczyszczenia
≤10
kolor
white
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
mouse ... Ngf(18049)
Opis ogólny
Nerve growth factor (NGF) is a dimer of 118-residue polypeptide chains linked non-covalently. Both these polypeptides contain three intramolecular disulphide bridges. It forms the prototype of the neurotrophin growth factor family. In male mouse submandibular salivary gland, NGF is present in high amounts, and is present as a high molecular weight complex called nerve growth factor-7S (NGF-7S). NGF-7S is an α2β2γ2 complex, where β2-NGF is the active neurotrophin, and is linked to the dimers of the glandular kallikrein serine proteinases members, α-NGF and γ-NGF.
Zastosowanie
Nerve Growth Factor-7S (NGF-7S) from murine submaxillary gland has been used for the treatment of following cells to induce neuronal differentiation-
- PC12
- Dorsal root ganglia (DRG) obtained from chick embryos of either sex (Gallus gallus)
Działania biochem./fizjol.
Nerve growth factor (NGF) is a neurotrophin, which facilitates the differentiation and survival of specific subtypes of neurons of central nervous system and peripheral nervous system. However, nerve growth factor-7S (NGF-7S) lacks any neurotrophic activity as most part of β-NGF subunit is buried within the NGF-7S complex.
Postać fizyczna
Lyophilized from 0.2 μm filtered solution in 25 mM sodium phosphate, pH 7.0.
Uwaga dotycząca przygotowania
Nerve growth factor-7S (NGF-7S) is isolated from male mouse submaxillary glands using a modification of the method of Varon, et al.
Komentarz do analizy
The biological activity is measured using a 3-day MTT assay.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
Certyfikaty analizy (CoA)
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