M7033

N^G-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

• Synonim(y): N_ω-Methyl-L-arginine acetate salt, L-NMMA, N⁵-(Methylamidino)-L-ornithine acetate salt, N^G-Monomethyl-L-arginine acetate salt
• Wzór empiryczny (zapis Hilla): C₇H₁₆N₄O₂ · C₂H₄O₂
• Numer CAS: 53308-83-1
• Masa cząsteczkowa: 248.28
• Beilstein: 6674255
• Numer MDL: MFCD00069311
• Kod UNSPSC: 12352209
• Identyfikator substancji w PubChem: 24278043
• NACRES: NA.77

Właściwości

• product name: N^G-Methyl-L-arginine acetate salt, ≥98% (TLC)
• Poziom jakości: 200
• Próba: ≥98% (TLC)
• Postać: powder
• rozpuszczalność: water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• ciąg SMILES: CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• Klucz InChI: IKPNWIGTWUZCKM-JEDNCBNOSA-N
• informacje o genach: human ... NOS1(4842) , NOS2(4843) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Nos1(24598) , Nos2(24599)

Opis

Zastosowanie

N^G-Methyl-L-arginine acetate salt has been used:

• as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice
• as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells
• as an inhibitor to monitor NO levels in hemocytes respiratory burst assay

Działania biochem./fizjol.

N^G-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

Cechy i korzyści

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)