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Kluczowe dokumenty
N5751
Nω-Nitro-L-arginine methyl ester hydrochloride
≥97% (TLC), powder, nitric oxide production inhibitor
Synonim(y):
L-NAME HCl, L-NAME hydrochloride
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About This Item
Wzór empiryczny (zapis Hilla):
C7H15N5O4 · HCl
Numer CAS:
Masa cząsteczkowa:
269.69
Beilstein:
3744166
Numer WE:
Numer MDL:
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
NACRES:
NA.77
Polecane produkty
Nazwa produktu
Nω-Nitro-L-arginine methyl ester hydrochloride, ≥97% (TLC), powder
pochodzenie biologiczne
synthetic
Próba
≥97% (TLC)
Formularz
powder
kolor
white to off-white
mp
132 °C
rozpuszczalność
H2O: 50 mg/mL
temp. przechowywania
−20°C
ciąg SMILES
Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
InChI
1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
Klucz InChI
QBNXAGZYLSRPJK-JEDNCBNOSA-N
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Opis ogólny
Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.
Zastosowanie
Nω-Nitro-L-arginine methyl ester hydrochloride has been used:
- to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons
- to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin
- to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells
- to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat
Działania biochem./fizjol.
Arginine analog that inhibits NO production.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Klienci oglądali również te produkty
L B Zou et al.
Neuropharmacology, 37(3), 323-330 (1998-07-29)
We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained
P Kubes et al.
The American journal of physiology, 262(2 Pt 2), H611-H615 (1992-02-01)
We recently demonstrated that inhibitors of nitric oxide (NO) production cause a dramatic increase in leukocyte adherence and emigration in postcapillary venules. The objective of this study was to assess whether inhibition of NO production leads to vascular protein leakage
Lisa Nguy et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R744-R752 (2013-03-22)
Rats with adenine-induced chronic renal failure (A-CRF) develop metabolic and cardiovascular abnormalities resembling those in patients with chronic kidney disease. The aim of this study was to investigate the mechanisms of hypertension in this model and to assess aortic stiffness
Protective effects of brain-derived neurotrophic factor against neurotoxicity of 3-nitropropionic acid in rat cortical neurons.
Wu CL, et al.
Neurotoxicology, 30(4), 718-726 (2009)
Amanda E Boe et al.
Circulation, 128(21), 2318-2324 (2013-10-05)
Long-term inhibition of nitric oxide synthase by L-arginine analogues such as N(ω)-nitro-l-arginine methyl ester (L-NAME) has been shown to induce senescence in vitro and systemic hypertension and arteriosclerosis in vivo. We previously reported that plasminogen activator inhibitor-1 (PAI-1)-deficient mice (PAI-1(-/-))
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