M4403

Monoclonal Anti-MAP2 antibody produced in mouse

clone HM-2, ascites fluid

• Synonim(y): MAP2 Antibody - Monoclonal Anti-MAP2 antibody produced in mouse, Map2 Antibody
• Numer MDL: MFCD00164683
• Kod UNSPSC: 12352203
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: mouse
• Poziom jakości: 200
• białko sprzężone: unconjugated
• forma przeciwciała: ascites fluid
• rodzaj przeciwciała: primary antibodies
• klon: HM-2, monoclonal
• masa cząsteczkowa: antigen ~280 kDa
• zawiera: 15 mM sodium azide
• reaktywność gatunkowa: rat, chicken, human, mouse, bovine, quail
• metody: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot: 1:1,000 using a fresh total rat brain extract or an enriched microtubule protein preparation
• izotyp: IgG1
• numer dostępu UniProt: P11137
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... MAP2(4133) ; mouse ... Mtap2(17756) ; rat ... Map2(25595)

Opis

Opis ogólny

Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are three forms of MAP2; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).

Specyficzność

Reacts with all known forms of MAP2, namely MAP2a, MAP2b and MAP2c. Does not cross-react with other MAPs or tubulin. By immunohistochemical staining of formalin-fixed, paraffin-embedded brain tissue, the antibody shows selective labeling of dendritic trees throughout the brain.

Immunogen

rat brain microtubule-associated proteins (MAPs).

Zastosowanie

Monoclonal Anti-MAP2 (2a+2b) antibody has been used in immunohistochemistry, immunostaining and western blotting.

Działania biochem./fizjol.

Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology.

Postać fizyczna

Supplied as ascites fluid with 15 mM sodium azide as a preservative.

Przechowywanie i stabilność

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): nwg
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable