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Key Documents

L9143

Sigma-Aldrich

Lipopolysaccharides from Pseudomonas aeruginosa 10

purified by phenol extraction

Synonim(y):

LPS

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About This Item

Numer MDL:
Kod UNSPSC:
12352201
NACRES:
NA.25

pochodzenie biologiczne

Pseudomonas aeruginosa (10)

Poziom jakości

Postać

lyophilized powder

oczyszczone przez

phenol extraction

zanieczyszczenia

<3% Protein (Lowry)

kolor

white to faint yellow

rozpuszczalność

water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

Warunki transportu

ambient

temp. przechowywania

2-8°C

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Opis ogólny

This product is phenol extracted from Pseudomonas aeruginosa serotype 10.22 The source strain is ATCC 27316.

Zastosowanie

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Działania biochem./fizjol.

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Uwaga dotycząca przygotowania

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Inne uwagi

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type N95 (US)


Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Keiko Yamauchi et al.
International journal of biological sciences, 5(7), 667-678 (2009-11-07)
Azithromycin (AZM), a 15-member macrolide antibiotic, possesses anti-inflammatory activity. Macrophages are important in innate and acquired immunity, and produce pro-inflammatory cytokines such as interleukin (IL)-12, which are composed of subunit p40 and p35. The key function of IL-12 is the
Khaled Taha-Abdelaziz et al.
Veterinary research, 47, 44-44 (2016-03-19)
β-defensins are an important element of the mucosal innate immune response against bacterial pathogens. Tracheal antimicrobial peptide (TAP) has microbicidal activity against the bacteria that cause bovine respiratory disease, and its expression in tracheal epithelial cells is upregulated by bacterial
Sudarshan Singh Rathore et al.
Scientific reports, 7(1), 15400-15400 (2017-11-15)
Cryptococcus neoformans infection is quite complex with both host-pathogen interaction and host immune profile determining disease progress and therapeutic outcome. Hence in the present study, the potential utility of (E)-5-benzylidenedihydrofuran-2(3 H)-one (compound-6) was explored as an effective anticryptococcal compound with immunomodulatory
Lesley Berghuis et al.
Veterinary research, 45, 105-105 (2014-10-12)
Bovine respiratory disease is a complex of bacterial and viral infections of economic and welfare importance to the beef industry. Although tracheal antimicrobial peptide (TAP) has microbicidal activity against bacterial pathogens causing bovine respiratory disease, risk factors for bovine respiratory
Kettani-Halabi Mohamed et al.
Plant signaling & behavior, 10(3), e1000160-e1000160 (2015-03-12)
Lipopolysaccharides (LPS) are a component of the outer cell surface of almost all Gram-negative bacteria and play an essential role for bacterial growth and survival. Lipopolysaccharides represent typical microbe-associated molecular pattern (MAMP) molecules and have been reported to induce defense-related

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