L4391
Lipopolysaccharides from Escherichia coli O111:B4
γ-irradiated, BioXtra, suitable for cell culture
Synonim(y):
LPS
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About This Item
Polecane produkty
pochodzenie biologiczne
Escherichia coli (O111:B4)
Poziom jakości
sterylność
γ-irradiated
linia produktu
BioXtra
Formularz
lyophilized powder
oczyszczone przez
gel-filtration chromatography
warunki przechowywania
desiccated
metody
cell based assay: suitable
cell culture | mammalian: suitable
zanieczyszczenia
<1% Protein (Lowry)
rozpuszczalność
H2O: 5 mg/mL, slightly hazy
Zastosowanie
clinical research
life science and biopharma
temp. przechowywania
2-8°C
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Opis ogólny
Lipopolysaccharides (LPS) are intricate molecules consisting of lipids and polysaccharides, predominantly present in the outer membrane of Gram-negative bacteria. Comprising lipid A, the core oligosaccharide (core), and the O-specific polysaccharide or O antigen (OAg), LPS is anchored to the outer bacterial membrane, with lipid A primarily responsible for its associated toxicity. Functioning as a potent activator of the proinflammatory response, LPS engages various mammalian cells, including macrophages, monocytes, and endothelial cells. While serving a protective role for Gram-negative bacteria against environmental stress, LPS also triggers recognition by the innate immune system during infections.
Zastosowanie
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
This LPS serotype has been used to stimulate B-cells and induce NOS in human hepatocytes.
Działania biochem./fizjol.
LPS is a major constituent of the cell wall of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. LPS also acts as a specific mitogen for bone marrow derived B lymphocytes from mice, rabbits, chickens, cows, hamsters, and humans.
Cechy i korzyści
- High-purity compound suitable for a wide variety of research applications
Rekonstytucja
Lipopolysaccharides are supplied as lyophilized, γ-irradiated powders. To reconstitute, add 1 ml sterile balanced salt solution or tissue culture medium to the vial (1 mg) and gently swirl until the powder dissolves. Reconstituted product may be further diluted to desired working concentrations using sterile balanced salt solution or tissue culture medium.
Inne uwagi
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Opis
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 2 Oral
Kod klasy składowania
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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