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L4021
Prolactin human
recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)
Synonim(y):
hPRL, LTH, Lactogenic Hormone, Luteotropic Hormone, PRL
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About This Item
Polecane produkty
pochodzenie biologiczne
Escherichia coli
Poziom jakości
rekombinowane
expressed in E. coli
opis
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
linia produktu
BioReagent
Próba
>97% (SDS-PAGE)
Formularz
lyophilized powder
siła działania
0.030-0.300 ng/mL EC50
masa cząsteczkowa
predicted mol wt ~24 kDa
metody
cell culture | mammalian: suitable
zanieczyszczenia
endotoxin, tested
rozpuszczalność
water: 0.5000 mL, clear, colorless
numer dostępu UniProt
Warunki transportu
ambient
temp. przechowywania
−20°C
informacje o genach
human ... PRL(5617)
Zastosowanie
Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.
Działania biochem./fizjol.
Neuroendocrine hormone; belongs to the cytokine hematopoietic receptor family; induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Inne uwagi
Contains an N-terminal methionine not present in the natural product.
Postać fizyczna
Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.
Rekonstytucja
It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.
Komentarz do analizy
The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Repr. 1B
Kod klasy składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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Regulatory action of prolactin on the in vitro growth of CD34+ve human hemopoietic progenitor cells.
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Etienne Delgrange et al.
European journal of endocrinology, 170(1), 31-38 (2013-10-04)
To characterise distinctive clinical features of giant prolactinomas in women. A multicentre, retrospective case series and literature review. We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and
Akie Nakamura et al.
The Journal of clinical endocrinology and metabolism, 98(10), E1682-E1691 (2013-08-24)
Congenital central hypothyroidism (C-CH) is a rare disease. We investigated the molecular basis of unexplained C-CH in 4 Japanese boys. C-CH was diagnosed by low free T4 and/or T3 and low basal TSH concentrations. We used whole-exome sequencing of one
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