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H7772

Sigma-Aldrich

Hygromycin B from Streptomyces hygroscopicus

lyophilized powder

Synonim(y):

Hygrovetine

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About This Item

Wzór empiryczny (zapis Hilla):
C20H37N3O13
Numer CAS:
31282-04-9
Masa cząsteczkowa:
527.52
Numer WE:
250-545-5
Numer MDL:
MFCD06795479
Kod UNSPSC:
51102829
Identyfikator substancji w PubChem:
24895807
NACRES:
NA.85

pochodzenie biologiczne

Streptomyces hygroscopicus

Poziom jakości

200

Formularz

lyophilized powder

oczyszczone przez

ion-exchange chromatography

kolor

faintly brown to brown
 white to beige

rozpuszczalność

H2O: 50 mg/mL

spektrum działania antybiotyku

viruses

Tryb działania

protein synthesis | interferes

temp. przechowywania

2-8°C

ciąg SMILES

CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3O[C@]4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

Klucz InChI

GRRNUXAQVGOGFE-XKIAHZFYSA-N

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Opis ogólny

Chemical structure: aminoglycoside

Zastosowanie

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes..

Działania biochem./fizjol.

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Przestroga

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

Uwaga dotycząca przygotowania

This product is purified by ion exchange chromatography. Hygromycin B is soluble in water at concentrations >50 mg/mL, and also soluble in methanol or ethanol. Solutions should be sterilized by filtration, not by autoclaving. Additionally, Hygromycin B solutions have been reported to lose activity on freezing, and since they are stable refrigerated, freezing should be avoided.
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Piktogramy

Skull and crossbones
GHS06

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300 + H310 + H330

Klasyfikacja zagrożeń

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
SLBZ3958
SLBV4266
SLBV3393
SLBS6931
SLBS4854

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Jeśli potrzebujesz konkretnej wersji, możesz wyszukać konkretny certyfikat według numeru partii lub serii.

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Séverine Lorrain et al.
The Plant cell, 16(8), 2217-2232 (2004-07-23)
The hypersensitive response (HR) is a programmed cell death that is commonly associated with plant disease resistance. A novel lesion mimic mutant, vad1 (for vascular associated death1), that exhibits light conditional appearance of propagative HR-like lesions along the vascular system
Claudine Balagué et al.
The Plant cell, 15(2), 365-379 (2003-02-05)
The hypersensitive response (HR) in plants is a programmed cell death that is commonly associated with disease resistance. A novel mutation in Arabidopsis, hlm1, which causes aberrant regulation of cell death, manifested by a lesion-mimic phenotype and an altered HR
Senthilkumar Padmanaban et al.
Plant physiology, 144(1), 82-93 (2007-03-06)
Guard cell movement is induced by environmental and hormonal signals that cause changes in turgor through changes in uptake or release of solutes and water. Several transporters mediating these fluxes at the plasma membrane have been characterized; however, less is
Sung Ki Cho et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(40), 15629-15634 (2008-09-24)
Abscission is a developmental program that results in the active shedding of infected or nonfunctional organs from a plant body. Here, we establish a signaling pathway that controls abscission in Arabidopsis thaliana from ligand, to receptors, to downstream effectors. Loss
Ben-Jiang Ma et al.
PLoS pathogens, 7(9), e1002200-e1002200 (2011-09-13)
The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies. One mechanism proposed for rarity of MPER neutralizing antibody generation is lack of reverted unmutated ancestor (putative
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Produkty

Inhibition of Protein Synthesis by Antibiotics

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome.

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