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H5527

Sigma-Aldrich

Hygromycin B solution from Streptomyces hygroscopicus

≥60% (HPLC), 45-60 mg/mL in H2O, γ-irradiated

Synonim(y):

Hygromycin b, Hygrovetine

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About This Item

Wzór empiryczny (zapis Hilla):
C20H37N3O13
Numer CAS:
31282-04-9
Masa cząsteczkowa:
527.52
Beilstein:
6755837
Numer MDL:
MFCD06795479
Kod UNSPSC:
51102829
Identyfikator substancji w PubChem:
24895698
NACRES:
NA.85

pochodzenie biologiczne

Streptomyces hygroscopicus

Poziom jakości

200

sterylność

γ-irradiated

stężenie

≥60% (HPLC)
45-60 mg/mL in H2O

kolor

yellow-brown to orange

spektrum działania antybiotyku

viruses

Tryb działania

protein synthesis | interferes

temp. przechowywania

2-8°C

ciąg SMILES

CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

Klucz InChI

GRRNUXAQVGOGFE-XKIAHZFYSA-N

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Opis ogólny

Chemical structure: aminoglycoside

Zastosowanie

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

Działania biochem./fizjol.

Mode of action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Przestroga

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

Uwaga dotycząca przygotowania

This product is a solution that is =60% (HPAE), 45-60 mg/mL in H2O, and γ-irradiated .
This page may contain text that has been machine translated.

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H301 + H311,H318,H330,H334

Zwroty wskazujące środki ostrożności

P260 - P280 - P284 - P301 + P310 - P305 + P351 + P338 - P310

Klasyfikacja zagrożeń

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Dam. 1 - Resp. Sens. 1

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certyfikaty analizy (CoA)

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