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H6541
Oncostatin M human
OSM, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Synonim(y):
OSM
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About This Item
Polecane produkty
pochodzenie biologiczne
human
Poziom jakości
rekombinowane
expressed in HEK 293 cells
Próba
≥95% (SDS-PAGE)
Formularz
lyophilized powder
siła działania
≤0.1-1.5 ng/mL EC50
jakość
endotoxin tested
masa cząsteczkowa
dimer 30 kDa (glycosylated)
opakowanie
pkg of 5X10 μg
pkg of 10 μg
metody
cell culture | mammalian: suitable
zanieczyszczenia
≤1 EU/μg
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... OSM(5008)
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Działania biochem./fizjol.
Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.
Postać fizyczna
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Komentarz do analizy
The activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (humanerythroleukemic indicator cell line)
Informacje prawne
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
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