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C002

Sigma-Aldrich

(±)-Quinuclidinyl benzilate

powder

Synonim(y):

(±)-QNB, (±)-Quinuclidinyl α-hydroxydiphenylacetate

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About This Item

Wzór empiryczny (zapis Hilla):
C21H23NO3
Numer CAS:
6581-06-2
Masa cząsteczkowa:
337.41
Numer MDL:
MFCD00055094
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329774757
NACRES:
NA.77

Postać

powder

kolor

white

rozpuszczalność

chloroform: soluble (but decomposes within 24 hrs)
methanol: stable (for up to two weeks at -20°C.)

εmax

13,500 at 207.4 nm in methanol

temp. przechowywania

2-8°C

ciąg SMILES

OC(C(=O)OC1CN2CCC1CC2)(c3ccccc3)c4ccccc4

InChI

1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2

Klucz InChI

HGMITUYOCPPQLE-UHFFFAOYSA-N

Działania biochem./fizjol.

Nonselective muscarinic acetylcholine receptor antagonist.

Cechy i korzyści

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This page may contain text that has been machine translated.

Piktogramy

Skull and crossbones
GHS06

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H300

Zwroty wskazujące środki ostrożności

P264 - P301 + P310

Klasyfikacja zagrożeń

Acute Tox. 2 Oral

Kod klasy składowania

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Monica Salani et al.
Journal of neurochemistry, 108(3), 821-834 (2009-02-04)
Neurotransmitters are considered part of the signaling system active in nervous system development and we have previously reported that acetylcholine (ACh) is capable of enhancing neuronal differentiation in cultures of sensory neurons and N18TG2 neuroblastoma cells. To study the mechanism
José N Nobrega et al.
Journal of pharmacological and toxicological methods, 86, 28-33 (2017-03-10)
Assessments of total anticholinergic activity (SAA) in serum are of considerable interest for its potential involvement in cognitive impairment associated with polydrug states in the elderly and other populations. Such estimations have been based on the displacement of radioligand binding
Koji Hori et al.
Neuropsychobiology, 63(3), 147-153 (2011-01-14)
Alzheimer's disease (AD) is well known as a disease characterized by degeneration of cholinergic neuronal activity in the brain. It follows that patients with AD would be sensitive to an 'anticholinergic burden', and also that medicine with anticholinergic properties would
Kylie J Mansfield et al.
The Journal of pharmacology and experimental therapeutics, 328(3), 893-899 (2008-11-26)
Recent studies have described muscarinic receptors on the mucosa and the detrusor of the human urinary bladder. Muscarinic receptor antagonists are effective in the treatment of overactive bladder (OAB), but their site(s) of action and actual therapeutic target are unclear.
Barbara C van Munster et al.
Journal of psychiatric research, 46(10), 1339-1345 (2012-08-01)
Delirium, a frequently occurring, devastating disease, is often underdiagnosed, especially in dementia. Serum anticholinergic activity (SAA) was proposed as a disease marker as it may reflect delirium's important pathogenetic mechanism, cholinergic deficiency. We assessed the association of serum anticholinergic activity
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