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Merck

74137

Sigma-Aldrich

D-chiro-Inositol

≥98.0% (HPLC)

Synonim(y):

D-(+)-chiro-Inositol, 1,2,4/3,5,6-Hexahydroxycyclohexane

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About This Item

Wzór empiryczny (zapis Hilla):
C6H12O6
Numer CAS:
Masa cząsteczkowa:
180.16
Numer WE:
Numer MDL:
Kod UNSPSC:
12352201
Identyfikator substancji w PubChem:
NACRES:
NA.25

Poziom jakości

Próba

≥98.0% (HPLC)

Postać

solid

aktywność optyczna

[α]/D 64.0±3.0°, c = 1 in H2O

kolor

white

mp

230 °C (lit.)

temp. przechowywania

2-8°C

ciąg SMILES

O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O

InChI

1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4-,5+,6+/m0/s1

Klucz InChI

CDAISMWEOUEBRE-LKPKBOIGSA-N

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Zastosowanie


  • D-chiro-inositol in clinical practice: An extensive review by The Experts Group on Inositol in Basic and Clinical Research presents D-chiro-inositol as a valuable substance in managing conditions like polycystic ovary syndrome, highlighting its clinical applications and potential benefits in metabolic syndrome management (Dinicola et al., 2024).

  • D-chiro-inositol enhancing longevity and antioxidant capacity: A study demonstrates that D-chiro-inositol boosts antioxidant capacity and extends lifespan in Caenorhabditis elegans through the activation of Nrf-2/SKN-1 and FOXO/DAF-16 pathways, suggesting its potential for optimizing dosage in age-related health interventions (Shi et al., 2023).

Działania biochem./fizjol.

Important second messenger in insulin signal transduction.

Inne uwagi

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Alessandro D Genazzani et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(6), 438-443 (2014-03-08)
Polycystic ovary syndrome (PCOS) is a common endocrine condition that affects fertility through oligo-ovulation, hyperandrogenism and polycystic morphology of the ovaries. Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate
J E Nestler et al.
The New England journal of medicine, 340(17), 1314-1320 (1999-04-29)
Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a D-chiro-inositol-containing phosphoglycan that mediates the action of insulin. We hypothesized that the administration of D-chiro-inositol would replenish stores of the mediator and
Ken-ichi Yoshida et al.
Applied and environmental microbiology, 72(2), 1310-1315 (2006-02-08)
D-chiro-inositol (DCI) is a drug candidate for the treatment of type 2 diabetes and polycystic ovary syndrome, since it improves the efficiency with which the body uses insulin and also promotes ovulation. Here, we report genetic modification of Bacillus subtilis
Hao-Han Chang et al.
Experimental biology and medicine (Maywood, N.J.), 240(1), 8-14 (2014-07-26)
Diabetic nephropathy is a serious complication of diabetes mellitus with a pressing need for effective metabolic markers to detect renal impairment. Of potential significance are the inositol compounds, myo-inositol (MI), and the less abundant stereoisomer, D-chiro-inositol (DCI), which are excreted
Alfonsa Pizzo et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 30(3), 205-208 (2013-12-20)
Myo-inositol and D-chiro-inositol are capable of improving the ovarian function and metabolism of polycystic ovary syndrome (PCOS) patients. The aim of this work is to compare the effects of myo-inositol and D-chiro-inositol in PCOS. We enrolled 50 patients, with homogeneous

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