PHR1602

Losartan Potassium

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonim(y): Losartan potassium, 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
• Wzór empiryczny (zapis Hilla): C₂₂H₂₂ClKN₆O
• Numer CAS: 124750-99-8
• Masa cząsteczkowa: 461.00
• Beilstein: 5845770
• Numer MDL: MFCD02092704
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329823502
• NACRES: NA.24

Właściwości

• klasa czystości: certified reference material; pharmaceutical secondary standard
• Poziom jakości: 300
• agency: traceable to BP 867; traceable to Ph. Eur. Y0001062; traceable to USP 1370462
• rodzina API: losartan
• Certyfikat analizy: current certificate can be downloaded
• opakowanie: pkg of 1 g
• metody: HPLC: suitable; gas chromatography (GC): suitable
• Zastosowanie: pharmaceutical (small molecule)
• format: neat
• temp. przechowywania: 2-30°C
• ciąg SMILES: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• Klucz InChI: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• informacje o genach: human ... AGTR1(185)

Opis

Opis ogólny

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Losartan Potassium is a novel class of orally active, non-peptide angiotensin II (type AT₁) receptor antagonist drug that can be used in the remedy of hypertension. It exhibits superior activity than many other peptide receptor antagonist drugs and angiotensin converting enzyme (ACE) inhibitors owing to the high specificity, selectivity, and tolerability.

Zastosowanie

Losartan Potassium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Działania biochem./fizjol.

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

Komentarz do analizy

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Inne uwagi

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Przypis

To see an example of a Certificate of Analysis for this material enter LRAC0141 in the slot below. This is an example certificate only and may not be the lot that you receive.

Polecane produkty

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable