61188

Losartan potassium

• Synonim(y): 2-Butyl-4-chloro-1-{[2′-(1H-tetrazol-5-yl)(1,1′-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol monopotassium salt, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- 1H-Imidazole-5-methanol potassium salt, DuP 753, MK 954, Potassium 5-(4′-((2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)tetrazol-1-ide
• Wzór empiryczny (zapis Hilla): C₂₂H₂₂ClKN₆O
• Numer CAS: 124750-99-8
• Masa cząsteczkowa: 461.00
• Beilstein: 5845770
• Numer MDL: MFCD02092704
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329759382
• NACRES: NA.24

Właściwości

• Postać: powder or crystals
• Poziom jakości: 200
• okres trwałości: limited shelf life, expiry date on the label
• metody: HPLC: suitable; gas chromatography (GC): suitable
• zanieczyszczenia: ≤0.5% water
• Zastosowanie: forensics and toxicology; pharmaceutical (small molecule); veterinary
• ciąg SMILES: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]
• InChI: 1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
• Klucz InChI: OXCMYAYHXIHQOA-UHFFFAOYSA-N
• informacje o genach: human ... AGTR1(185)

Opis

Opis ogólny

Losartan potassium has long lasting effects, and its efficacy is generally increased, when combined with the diuretic co-active hydrochlorothiazide.

Losartan potassium is an antihypertensive drug that is found to be an angiotensin II receptor type 1 blocker. It finds applications in reducing mechanical stress thereby having a control over the condition of cardiac hypertrophy.

Zastosowanie

Losartan potassium may be used as an analytical reference standard for the quantification of the analyte in the following:

• Pharmaceutical formulations using reversed-phase high-performance liquid chromatography and UV-spectrophotometric techniques.
• Rat plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS) technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Działania biochem./fizjol.

Losartan potassium is an orally available, potent, and selective competitive angiotensin II receptor type 1 (AT1) antagonist. Losartan potassium is used for treatment of hypertension.

Polecane produkty

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)