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C2430000

Clotrimazole

European Pharmacopoeia (EP) Reference Standard

Synonim(y):

1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole

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About This Item

Wzór empiryczny (zapis Hilla):
C22H17ClN2
Numer CAS:
23593-75-1
Masa cząsteczkowa:
344.84
Numer MDL:
MFCD00057220
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329775002
NACRES:
NA.24

klasa czystości

pharmaceutical primary standard

rodzina API

clotrimazole

producent / nazwa handlowa

EDQM

Zastosowanie

pharmaceutical (small molecule)

format

neat

ciąg SMILES

Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4

InChI

1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H

Klucz InChI

VNFPBHJOKIVQEB-UHFFFAOYSA-N

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Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Zastosowanie

Clotrimazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.
This page may contain text that has been machine translated.

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Piktogramy

Exclamation markEnvironment
GHS07,GHS09

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H302,H315,H319,H410

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

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Certyfikaty analizy (CoA)

Lot/Batch Number

Przepraszamy, ale COA dla tego produktu nie jest aktualnie dostępny online.

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Dermatologica, 169 Suppl 1, 51-55 (1984-01-01)
The retention time and the extent of penetration in human skin of [14C] labelled bifonazole in comparison to [14C] labelled clotrimazole were investigated in 8 healthy volunteers. In the course of the investigation the backs of the volunteers were treated
Maria F Sassano et al.
Journal of medicinal chemistry, 56(6), 2406-2414 (2013-02-27)
Colloidal aggregation is the dominant mechanism for artifactual inhibition of soluble proteins, and controls against it are now widely deployed. Conversely, investigating this mechanism for membrane-bound receptors has proven difficult. Here we investigate the activity of four well-characterized aggregators against
Natalia Mast et al.
Molecular pharmacology, 84(1), 86-94 (2013-04-23)
Although there are currently three generations of antifungal azoles on the market, even the third-generation agents show undesirable interactions with human cytochrome P450 (P450) enzymes. CYP46A1 is a cholesterol-metabolizing P450 in the brain that tightly binds a number of structurally
Laura Ravani et al.
International journal of pharmaceutics, 454(2), 695-702 (2013-06-25)
The aim of the present work is to design a new formulation containing clotrimazole (CTZ) loaded into nanostructured lipid carriers (NLC) for the treatment of fungal vaginal infections. In order to obtain formulations with suitable viscosity for mucosal application, NLC
Jenna Corcoran et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 57-65 (2014-04-15)
Clotrimazole (CTZ) is a persistent imidazole antifungal agent which is frequently detected in the aquatic environment and predicted to bio-concentrate in fish. Common carp (Cyprinus carpio) were exposed to mean measured concentrations of either 1.02 or 14.63μgl(-1) CTZ for 4
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