Wszystkie zdjęcia(2)
Kluczowe dokumenty
B4380
Bromobimane
≥97% purity, powder
Synonim(y):
Monobromobimane
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About This Item
Wzór empiryczny (zapis Hilla):
C10H11BrN2O2
Numer CAS:
Masa cząsteczkowa:
271.11
Beilstein:
4430959
Numer MDL:
Kod UNSPSC:
12171500
Identyfikator substancji w PubChem:
NACRES:
NA.47
Polecane produkty
Nazwa produktu
Bromobimane, ≥97% (HPLC)
Poziom jakości
Próba
≥97% (HPLC)
Formularz
powder
kolor
yellow
mp
161 °C
rozpuszczalność
acetonitrile: 20 mg/mL
ε (współczynnik ekstynkcji)
4.6-5.1 at 396-398 nm in H2O
Zastosowanie
diagnostic assay manufacturing
hematology
histology
temp. przechowywania
−20°C
ciąg SMILES
CC1=C(C)C(=O)N2N1C(CBr)=C(C)C2=O
InChI
1S/C10H11BrN2O2/c1-5-7(3)12-8(4-11)6(2)10(15)13(12)9(5)14/h4H2,1-3H3
Klucz InChI
AHEWZZJEDQVLOP-UHFFFAOYSA-N
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Opis ogólny
Bromobimane is also known as monobromobimane. It is also a known probe for thiols and is a fluorescent reagent activated upon a photolysis reaction.
Zastosowanie
Bromobimane is used for the determination of thiols by the HPLC method. It is suitable as a pre-column derivatization agent for fluorometric determination of 2,3-dimercaptopropane-1-sulfonic acid and other dithiols. Bromobimane has been used as a fluorescent label in studying oligomycin-sensitive ATPase from beef heart mitochondria.
Bromobimane has been used for the quantitative measurement of free hydrogen sulfide in vivo and in vitro. It has been used for the labeling of proteins containing thiol groups.
Bromobimane has been used for the quantitative measurement of free hydrogen sulfide in vivo and in vitro. It has been used for the labeling of proteins containing thiol groups.
Działania biochem./fizjol.
Bromobimane in solution reacts with small thiol groups (e.g., GSH) and with reactive protein thiol groups (e.g., hemoglobin). The reaction of Bromobimane with thiols is of second-order and dependent on pH and upon reacting with thiolate, it activates the water-soluble fluorescent product for detection.
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Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 3
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type N95 (US)
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Hydrogen sulphide (H(2)S) is a labile, endogenous metabolite of cysteine, with multiple biological roles. The development of sulphide-based therapies for human diseases will benefit from a reliable method of quantifying H(2)S in blood and tissues. Concentrations of reactive sulphide in
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