579050

TAPI-0

≥96% (HPLC), solid, collagenase, gelatinase, and TACE inhibitor, Calbiochem^®

• Synonim(y): TAPI-0, N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide, TNF-α Protease Inhibitor-0
• Wzór empiryczny (zapis Hilla): C₂₄H₃₂N₄O₅
• Numer CAS: 143457-40-3
• Masa cząsteczkowa: 456.53
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Nazwa produktu: TAPI-0, TAPI-0, CAS 143457-40-3, is a hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM).
• Poziom jakości: 100
• Próba: ≥96% (HPLC)
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic); protect from light
• kolor: white
• rozpuszczalność: 50% acetic acid: 1 mg/mL; DMSO: 5 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: −20°C
• InChI: 1S/C24H32N4O5/c1-14(2)10-19(13-21(29)28-33)23(31)27-20(24(32)26-15(3)22(25)30)12-16-8-9-17-6-4-5-7-18(17)11-16/h4-9,11,14-15,19-20,33H,10,12-13H2,1-3H3,(H2,25,30)(H,26,32)(H,27,31)(H,28,29)/t15-,19?,20-/m0/s1
• Klucz InChI: CRCPLBFLOSEABN-VBSNWNEZSA-N

Opis

Opis ogólny

A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). Blocks spontaneous and PMA-induced release of TNF-α in transfected COS 7 cells.

A hydroxymate-based inhibitor of collagenase, gelatinase, and TACE [(TNF-α convertase; ADAM17 (IC₅₀ = 100 nM)]. Blocks spontaneous and PMA-induced release of TNF-α from transfected COS-7 cells.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
TNF-α converting enzyme/ADAM17

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM against TACE (TNF-α converting enzyme/ADAM17)

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Inne uwagi

Hooper, N.M., et al. 1997. Biochem. J.321, 265.
Mullberg, J., et al. 1995. J. Immunol.155, 5198.
Mohler, K.M., et al. 1994. Nature370, 218.

Informacje prawne

Manufactured exclusively by Peptides International, Louisville, Kentucky, USA.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable