238900

4-Cyano-3-methylisoquinoline

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM).

• Synonim(y): 4-Cyano-3-methylisoquinoline, PKA Inhibitor XI
• Wzór empiryczny (zapis Hilla): C₁₁H₈N₂
• Numer CAS: 161468-32-2
• Masa cząsteczkowa: 168.19
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Postać: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze
• kolor: white
• rozpuszczalność: DMSO: 50 mg/mL
• Warunki transportu: ambient
• temp. przechowywania: 2-8°C
• InChI: 1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3
• Klucz InChI: SZWLGBJCLZDZBY-UHFFFAOYSA-N

Opis

Opis ogólny

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.

A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).

Działania biochem./fizjol.

Cell permeable: yes

Primary Target
PKA

Product competes with ATP.

Reversible: yes

Target IC₅₀: 30 nM against protein kinase A

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Inne uwagi

Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable