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SML0002

Sigma-Aldrich

C646

≥98% (HPLC)

Synonim(y):

4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

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About This Item

Wzór empiryczny (zapis Hilla):
C24H19N3O6
Numer CAS:
328968-36-1
Masa cząsteczkowa:
445.42
Numer MDL:
MFCD01784780
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329825079
NACRES:
NA.77

Poziom jakości

100

Próba

≥98% (HPLC)

Formularz

powder

warunki przechowywania

desiccated

kolor

red to brown

rozpuszczalność

DMSO: >25 mg/mL

temp. przechowywania

2-8°C

ciąg SMILES

Cc1cc(-c2ccc(\C=C3\C(C)=NN(c4ccc(cc4)C(O)=O)C3=O)o2)c(cc1C)[N+]([O-])=O

InChI

1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-

Klucz InChI

HEKJYZZSCQBJGB-UNOMPAQXSA-N

Zastosowanie

C646 was used to study the role of p300 in chronic neuropathic pain in rats with chronic constriction injury.

Działania biochem./fizjol.

C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases.
C646 is a potent, cell permeable and selective inhibitor of p300 and CBP (p300/CBP) histone acetyltransferases. Inhibition of p300/CBP by C646 affects the activity of a variety of transcriptional factors such as NF-κB, p53 and MyoD that are associated with physiology, disease processes, hippocampal synaptic plasticity, spatial memory and contextual fear.

Cechy i korzyści

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Wybierz jedną z najnowszych wersji:

Certyfikaty analizy (CoA)

Lot/Batch Number
106M4611V
104M4614V
073M4602V
102M4614V
021M4618V

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Histone Modification and Chromatin Remodeling | Epigenetics

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