176695

Angeli′s Salt

A nitroxyl anion (NO⁻) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound.

• Synonim(y): Angeli’s Salt, Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
• Wzór empiryczny (zapis Hilla): N₂O₃ · 2Na
• Numer CAS: 13826-64-7
• Masa cząsteczkowa: 121.99
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥99%
• Postać: crystalline solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic); protect from light
• rozpuszczalność: alkaline solution: soluble (0.01 M NaOH)
• Warunki transportu: wet ice
• temp. przechowywania: −20°C

Opis

Opis ogólny

A nitroxyl anion (NO^–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t_½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.

A nitroxyl anion (NO^-) donor that spontaneously, in the presence of oxygen and Cu²⁺ and Fe³⁺, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t_½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC₅₀ = 590 nM). Angeli′s Salt produces nitroxyl anion (NO^-) that can be converted to NO in the presence of heme.

Działania biochem./fizjol.

Cell permeable: no

Primary Target
Nitroxyl anion (NO-) donor

Product does not compete with ATP.

Reversible: no

Opakowanie

Packaged under inert gas

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.

Inne uwagi

Miranda, K.M., et al. 2001. J. Biol. Chem.276, 1720.
Hrinczenko, B.W., et al. 2000. Br. J. Haematol.110, 412.
Nelli, S., et al. 2000. Br. J. Pharmacol.131, 356.
Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA96, 14617.
Keefer, L.K., et al. 1996. Methods Enzymol.268, 281.
Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun.196, 707.
Maragos, C.M., et al. 1991. J. Med. Chem.34, 3242.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable