A1887

Albumin from human serum

lyophilized powder, essentially fatty acid free

• Synonim(y): HSA
• Numer CAS: 70024-90-7
• Numer WE: 274-272-6
• Numer MDL: MFCD00081418
• Kod UNSPSC: 12352202
• eCl@ss: 42010201
• NACRES: NA.25

Właściwości

• pochodzenie biologiczne: human
• Poziom jakości: 300
• Próba: ≥96% (agarose gel electrophoresis)
• Postać: lyophilized powder
• masa cząsteczkowa: monomer calculated mol wt 66478 Da
• metody: ELISA: suitable; tissue culture: suitable; western blot: suitable
• zanieczyszczenia: HIV I and HIVII, HCV and HBsAg, tested negative; ≤0.007% Fatty Acids
• rozpuszczalność: H₂O: soluble 50 mg/mL, clear to slightly hazy
• numer dostępu UniProt: P02768
• temp. przechowywania: 2-8°C
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• Klucz InChI: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• informacje o genach: human ... ALB(213)

Opis

Opis ogólny

Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.

Zastosowanie

Albumin from human serum has been used:

• as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
• to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
• to study its effect on wound healing process

Działania biochem./fizjol.

Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influence their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has widely varied effects on its physiological function.

Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.

Uwaga dotycząca przygotowania

Prepared from albumin (A1653)

Inne uwagi

View more information on human serum albumin.

Oświadczenie o zrzeczeniu się odpowiedzialności

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves