14-555-M
Białko alkaliczne, aktywne, 10 µg
Active, N-terminal His6-tagged, recombinant human ALK, residues 1058-end, for use in Kinase Assays.
Synonim(y):
Kinaza chłoniaka anaplastycznego
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About This Item
Kod UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
Poziom jakości
rekombinowane
expressed in baculovirus infected Sf21 cells
masa cząsteczkowa
Mw 63.8 kDa
producent / nazwa handlowa
Upstate®
metody
activity assay: suitable (kinase)
numer dostępu NCBI
numer dostępu UniProt
Opis ogólny
Research area: CELL SIGNALING
Product Source: expressed by baculovirus in Sf21 cells
The anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily of receptor tyrosine kinases. The ALK gene is located on human chromosome 2p23 and shares a high similarity with the leukocyte tyrosine kinase (Ltk). ALK is composed of three domains: an extracellular domain responsible for ligand binding, a transmembrane domain that spans the cell membrane, and a cytoplasmic domain housing the tyrosine kinase activity. The cytoplasmic tyrosine kinase domain of ALK plays a significant role in disease pathologies associated with the gene. Within the structure, there are two short conserved β-strands (β7-β8) housing majority of the catalytic residues. Full-length ALK is specifically expressed in the developing central and peripheral nervous systems during embryogenesis and is associated with the balance of cell proliferation and differentiation.
Product Source: expressed by baculovirus in Sf21 cells
The anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily of receptor tyrosine kinases. The ALK gene is located on human chromosome 2p23 and shares a high similarity with the leukocyte tyrosine kinase (Ltk). ALK is composed of three domains: an extracellular domain responsible for ligand binding, a transmembrane domain that spans the cell membrane, and a cytoplasmic domain housing the tyrosine kinase activity. The cytoplasmic tyrosine kinase domain of ALK plays a significant role in disease pathologies associated with the gene. Within the structure, there are two short conserved β-strands (β7-β8) housing majority of the catalytic residues. Full-length ALK is specifically expressed in the developing central and peripheral nervous systems during embryogenesis and is associated with the balance of cell proliferation and differentiation.
Zastosowanie
Research Category
Inflammation & Immunology
Inflammation & Immunology
Działania biochem./fizjol.
Protein Target: ALK
Target Sub-Family: TK Anaplastic lymphoma kinase (ALK) plays a crucial role in the development of neurons. Binding of ligand to its extracellular domain triggers the activation of the tyrosine kinase that in turn activates the mitogen-activated protein kinase (MAPK) pathway. ALK fusion proteins induce the activation of diverse pathways including Phospholipase C gamma (PLC-γ) and Ras/Extracellular Signal-Regulated Kinase 1/2 (Ras/ERK1/2), which contribute to cell proliferation, while the Janus Kinase/signal transducer and activator of transcription (JAK/STAT) pathway and Phosphoinositide 3-kinase/Protein Kinase B (PI3K/Akt) pathways facilitate cell survival. Notably, ALK has been found to be overexpressed in various human tumors and cell lines such as lymphomas, neuroblastoma, and non-small-cell lung cancer.
Target Sub-Family: TK Anaplastic lymphoma kinase (ALK) plays a crucial role in the development of neurons. Binding of ligand to its extracellular domain triggers the activation of the tyrosine kinase that in turn activates the mitogen-activated protein kinase (MAPK) pathway. ALK fusion proteins induce the activation of diverse pathways including Phospholipase C gamma (PLC-γ) and Ras/Extracellular Signal-Regulated Kinase 1/2 (Ras/ERK1/2), which contribute to cell proliferation, while the Janus Kinase/signal transducer and activator of transcription (JAK/STAT) pathway and Phosphoinositide 3-kinase/Protein Kinase B (PI3K/Akt) pathways facilitate cell survival. Notably, ALK has been found to be overexpressed in various human tumors and cell lines such as lymphomas, neuroblastoma, and non-small-cell lung cancer.
Jakość
routinely evaluated by phosphorylation of IGF-1Rtide
Postać fizyczna
Ni2+/NTA-agarose
Przechowywanie i stabilność
6 months at -70°C from date of shipment
Inne uwagi
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Informacje prawne
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Expression of anaplastic lymphoma kinase in non-Hodgkin's lymphomas and other malignant neoplasms. Biological, diagnostic, and clinical implications.
Wasik, Mariusz A
American Journal of Clinical Pathology, 118 Suppl, S81-S92 (2002)
K Pulford et al.
Cellular and molecular life sciences : CMLS, 61(23), 2939-2953 (2004-12-08)
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, the normal role of which remains to be completely elucidated. Although work carried out in mammals suggests a function in neural development, results from studies in Drosophila indicate an additional role
Anaplastic lymphoma kinase proteins in growth control and cancer.
Pulford, K, et al.
Journal of Cellular Physiology, 199, 330-358 (2004)
ALK a novel lymphoma-associated tumor antigen for vaccination strategies.
Passoni, Lorena and Gambacorti-Passerini, Carlo
Leukemia & Lymphoma, 44, 1675-1681 (2003)
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